Na^+-Ca^<2+> Exchanger Expression and Its Modulation(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
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概要
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Here we reviewed our recent work on the chronic effects of nicotine on the Na^+-Ca^<2+> exchanger (NCX) gene and protein expressions in various organs of rats treated with nicotine in the drinking water for 4-12 weeks. Microarray analysis and reverse transcriptase-polymerase chain reaction (RT-PCR) did not detect significant changes in NCX mRNA expression in cerebral cortex, hippocampus, heart and skeletal muscle. However, NCX1 protein was up-regulated by nicotine in cerebral cortex and hippocampus, but was down-regulated in the heart. NCX2 protein was up-regulated by nicotine in hippocampus. We suggest that although mRNA change was in-significant, NCX protein expression was altered by chronic nicotine administration in brain and heart in rats. We also reviewed our work on modulators of NCX gene expression and function in cardiac myocytes.
- 公益社団法人日本薬学会の論文
- 2009-03-01
著者
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Kimura Junko
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Toho University
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WATANABE Shinya
Department of Clinical Genomics, Translational Research Center (Tokyo Branch), Fukushima Medical Uni
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Sakamoto Kazuho
Department of Pharmacology, School of Medicine, Fukushima Medical University, Japan
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Ono Tomoyuki
Department of Pharmacology, School of Medicine, Fukushima Medical University, Japan
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Kimura J
Dep. Of Pharmacology School Of Medicine Fukushima Medical Univ. Jpn
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Ito Emi
Department of Bioengineering, Nagaoka University of Technology
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Sasaki Yatabe
Department Of Pharmacology Fukushima Medical University School Of Medicine
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Ito Emi
Department Of Clinical Informatics Tokyo Medical And Dental University School Of Medicine
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Ito Emi
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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Kimura J
Department Of Pharmacology Fukushima Medical University School Of Medicine
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Ono Tomoyuki
Department Of Pharmacology Fukushima Medical University School Of Medicine
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Ono Tomoyuki
Department Of Pharmacology Fukushima Medical College
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MATSUOKA Isao
Department of Pharmacology, Fukushima Medical University, School of Medicine
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Matsuoka Isao
Department Of Pharmacology Fukushima Medical College
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Maeda Sachiko
Department Of Pharmacology Fukushima Medical University School Of Medicine
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Maeda Sachiko
Department Of Biology Faculty Of Science Kobe University
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SHIKAMA Yayoi
Department of Pharmacology, Fukushima Medical University, School of Medicine
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Shikama Yayoi
Department Of Pharmacology Fukushima Medical University School Of Medicine
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Sakamoto Kazuho
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Watanabe Shinya
Department Of Chemical Engineering Nagoya University
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Watanabe Shinya
Department Of Clinical Informatics Tokyo Medical And Dental University School Of Medicine
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Sakamoto Kazuho
Department Of Pharmacology School Of Medicine Fukushima Medical University
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Matsuoka Isao
Department Of Anesthesiology Ilikai Medical Inc Kakizoe Hospital
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WATANABE Shinya
Department of Animal Breeding and Reproduction, NARO Institute of Livestock and Grassland Science, Ibaraki 305-0901, Japan
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