A Novel Opener of Large-Conductance Ca^<2+>-Activated K^+ (BK) Channel Reduces Ischemic Injury in Rat Cardiac Myocytes by Activating Mitochondrial K_<Ca> Channel
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概要
- 論文の詳細を見る
It has been suggested that a new type of large-conductance Ca2+-activated K+ (BK) channel is distributed in the inner mitochondrial membrane (mitoKCa channel) and that its opening may attenuate ischemic cardiac injury. We examined effects of 12,14-dichlorodehydroabietic acid (diCl-DHAA), a novel BK-channel opener, on rat cardiac myocytes and mitochondria. Application of diCl-DHAA concentration-dependently reduced Ca2+ overload in isolated mitochondria, activated mitoKCa channels in inside-out patches of mitochondrial membrane, facilitated flavoprotein-oxidization in myocytes, and increased cellular viability under simulated ischemia. In conclusion, diCl-DHAA directly opens mitoKCa channels, prevents Ca2+ influx into matrix, and reduces ischemic injury in cardiac myocytes.
- 社団法人 日本薬理学会の論文
- 2008-09-20
著者
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OHYA Susumu
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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IMAIZUMI Yuji
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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Sakamoto Kazuho
Department of Pharmacology, School of Medicine, Fukushima Medical University, Japan
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村木 克彦
名古屋市大・院・細胞分子薬効解析
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Muraki Katsuhiko
Department Of Cellular Pharmacology School Of Pharmacy Aichi-gakuin University
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村木 克彦
Department Of Cellular Pharmacology School Of Pharmacy Aichi-gakuin University
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Ishii Yoko
大分医科大学臨床薬理学
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Ohya Susumu
Dep. Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City U
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Ohya Susumu
Department Of Molecular & Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoy
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Imaizumi Y
Dep. Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City U
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Imaizumi Yuji
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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MURAKI Katsuhiko
Laboratory of Cellular Pharmacology, School of Pharmacy, Aichi Gakuin University
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Sakamoto Kazuho
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Ishii Yatsuka
Department Of Clinical Pharmacology And Therapeutics Oita Medical University
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Sakamoto Kazuho
Department Of Pharmacology School Of Medicine Fukushima Medical University
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