Cell-Cycle-Dependent Regulation of Ca^<2+>-Activated K^+ Channel in Jurkat T-Lymphocyte
スポンサーリンク
概要
- 論文の詳細を見る
Small-conductance Ca2+-activated K+ (SK2) channel plays an important role in the activation of Jurkat T-lymphocytes by maintaining electrical gradients for the sustained Ca2+ influx. Apamin-sensitive K+ current was significantly decreased with cell-cycle progression from G0/G1 into G2/M phases, and protein expression of SK2 channels showed parallel down-regulation, with its highest expression at early G0/G1 phase. In the G0/G1 phase, the apamin-sensitive component of thapsigargin-induced Ca2+ influx was significantly larger than that in the G2/M phase. These observations suggest that SK2-channel activation may largely contribute to the sustained Ca2+ influx in the G0/G1 phase in comparison of that in the G2/M phase in Jurkat T-lymphocytes.
- 社団法人 日本薬理学会の論文
- 2007-05-20
著者
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OHYA Susumu
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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IMAIZUMI Yuji
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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MORIMOTO TAKASHI
Department of Surgery II, Osaka University Medical School
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HAYASHI Hidetoshi
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences
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Hayashi Hidetoshi
Department Of Molecular Health Sciences Graduate School Of Pharmaceutical Sciences Nagoya City Unive
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Hayashi Hidetoshi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Kanazawa University
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ONOZAKI Kikuo
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City Uni
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Morimoto Takashi
Department Of Applied Biological Chemistry The University Of Tokyo
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Ohya Susumu
Department Of Molecular & Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoy
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Onozaki Kikuo
Department Of Molecular Health Sciences Graduate School Of Pharmaceutical Sciences Nagoya City Unive
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Onozaki Kikuo
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Imaizumi Yuji
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Imaizumi Yuji
Department Of Molecular & Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoy
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Morimoto Takashi
Department Of Molecular & Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoy
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Onozaki Kikuo
Department Of Molecular Health Sciences Graduate School Of Pharmaceutical Sciences Nagoya City Unive
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