Involvement of Interleukin-6 in Activation of Lysosomal Cathepsin and Atrophy of Muscle Fibers Induced by Intramuscular Injection of Turpentine Oil in Mice.
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概要
- 論文の詳細を見る
Serum IL-6 level increased after the injection of turpentine oil into the right gastrocnemius muscle in mice. The mRNA level of IL-6 was highest in the injected muscle at 12h after injection, but was not identified in the opposite muscle. The activities of cathepsins B and B+L started to elevate after 12h in the injected muscle and markedly increased after day 3. Likewise, the mRNA levels of cathepsins B and L markedly increased from day 1 to day 5 in the injected muscle. However, a very mild increase was also observed in the opposite muscle. Immunohistochemical staining of cathepsins B and L exhibited positive reactions as fine granules in myofibers at 12h and strong positive reactions in the infiltrating macrophages at 3 days. Atrophy of myofibers type 1 and 2 was evident in a time-dependent manner in the injected muscle. Treatment with rat anti-mouse IL-6 receptor monoclonal antibody inhibited the increase in cathepsin activities in the injected muscle. We conclude that IL-6 produced in the inflamed muscle is involved in the process of muscle degeneration, especially through the activation of lysosomal cathepsins.
- 社団法人 日本生化学会の論文
著者
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Kominami Eiki
Department Of Biochemistry Faculty Of Medicine Juntendo University
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Ogawa Atsuhiro
Department Of Internal Medicine Shiga University Of Medical Science
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Ebisui Chikara
Department Of Surgery Hyogo Prefectural Nishinomiya Hospital
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Morimoto Takashi
Department Of Applied Biological Chemistry The University Of Tokyo
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Tsujinaka Toshimasa
Department Of Surgery National Hospital Organization Osaka National Hospital
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Yano Masahiko
Department Of Breast And Endocrine Surgery Hyogo College Of Medicine
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Shiozaki Hitoshi
Department Of Surgery Ii Osaka University Medical School
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Kishibuchi Masanori
Department Of Surgery Ii Osaka University Medical School
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Monden Morito
Department Of Gastroenterological Surgery Osaka University Graduate School Of Medicine
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Fujita Junya
Department of Electrical Engineering and Bioscience, Waseda University, Shinjuku, Tokyo 169-8555, Japan
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