Extinction of Organelles in Differentiating Epidermis

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概要

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• In the dorsal skin of fetal rats, the epidermis on day 16 of gestation consisted of a single or a few layers of undifferentiated cells, and it developed to display the full strata, i.e.the stratum(s.)corneum(horny layer), s.granulosum(granular layer), s.spinosum(spinous layer), and s.germinativum(basal layer)by the day of birth. Perinuclear electron lucent special areas, which were also detectable by conventional staining under light microscope, appeared in the cells of the s.spinosum or the s.granulosum on the day of birth. We call such an area the "perinuclear compartment(PNC)". The PNC was not partitioned by membranous structures either. Typical PNCs became recognizable on the day of birth. The cell nuclei seemed to be digested inside of the PNC of the cells located in the outermost area of the s.granulosum or sometimes in the boundary between the s.granulosum and the s.corneum. In the initial phase of nuclear extinction, morphology of the nucleus undergoing degeneration resembles that of apoptotic cells. In comparison to the morphological degeneration of the nucleus, DNA fragmentation was suggested to occur earlier. Localization of cathepsin B and cathepsin D in the s.spinosum and s.granulosum as revealed by immunohistochemistry, together with an electron microscopic study on the appearance of autophagosomes in those areas, suggested a contribution of autophagy to the digestion of organelles including mitochondria and endoplasmic reticula in the terminal differentiation of epdermal cells.

• 日本組織細胞化学会の論文

著者

• Kominami Eiki

  Department of Biochemistry, Juntendo University School of Medicine

• SAKURABA HITOSHI

  Department of Clinical Genetics, the Tokyo Metropolitan Institute of Medical Science, Tokyo Metropol

• UENO Takashi

  Department of Dermatology, Nippon Medical School

• Sakuraba H

  Department Of Analytical Biochemistry Meiji Pharmaceutical University

• Ueno Takashi

  Department Of Biochemistry Juntendo University School Of Medicine

• Ueno T

  Toxicological Research Center Nitto Denko Corporation

• Kominami E

  Department Of Biochemistry Juntendo University School Of Medicine

• Kominami Eiki

  Dep. Of Biochemistry Juntendo Univ. School Of Medicine

• Kominami Eiki

  Department Of Biochemistry Faculty Of Medicine Juntendo University

• Ueno Takashi

  Dept. of Biochemistry, Juntendo University, School of medicine

• Sakuraba HItoshi

  Dept. of Clin. Genet., The Tokyo Metropolitan Inst. Med. Sci

• Ihara Setsunosuke

  Dept. of Biol. ScL, Shimane University, School of Life and Environmental Science

• Morioka Kiyokazu

  Department of Clinical Genetics, The Tokyo Metropolitan Institute of Medical Science

• Ihara Setsunosuke

  Department of Biological Science, Faculty of Life and Environmental Science, Shimane University

• Sakuraba Hitoshi

  Department Of Analytical Biochemistry Meiji Pharmaceutical University

• Sakuraba Hitoshi

  Dept. Of Clin. Genet. The Tokyo Metropolitan Inst. Med. Sci

• Morioka Kiyokazu

  Dept. Of Clin. Genet. The Tokyo Metropolitan Inst. Med. Sci

• Morioka Kiyokazu

  Department Of Clinical Genetics The Tokyo Metropolitan Institute Of Medical Science

• Ihara Setsunosuke

  Dept. Of Biol. Scl Shimane University School Of Life And Environmental Science

• Ihara Setsunosuke

  Department Of Biological Science Faculty Of Life And Environmental Science Shimane University

• Takano-ohmuro Hiromi

  Department Of Pharmacology Faculty Of Medicine The University Of Tokyo

• Morioka K

  The Tokyo Metropolitan Institute Of Medical Science

• Takano‐ohmuro H

  Department Of Pharmacology Faculty Of Medicine University Of Tokyo

• Ueno T

  Toshiba Corp. Kawasaki‐shi Jpn

• Ueno Takashi

  Dept. Of Biochemistry Juntendo University School Of Medicine

• Sameshima Masasumi

  Department of Cell Biology, The Tokyo Metropolitan Institute of Medical Science

• Sameshima Masasumi

  Department Of Cell Biology The Tokyo Metropolitan Institute Of Medical Science

• Ueno Takashi

  Department Of Bio-medical Engineering Tokai University

• Sakuraba H

  Department Of Tumor Immunology And Clinical Genetics Tokyo Metropolitan Institute Of Medical Science

• Ueno Takashi

  Department Of Applied Chemistry Faculty Of Science And Engineering Ritsumeikan University

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