Electron microscopical and immunohistochemical studies on the localization of cathepsin B, D, L, LAMP-1 and μ-calpain in developing hair follicles
スポンサーリンク
概要
- 論文の詳細を見る
Development of hair follicle implies the coordinated differentiation of multilayers of cells that lie in external/internal root sheaths and hair shaft. During differentiation of layers in the internal root sheath and hair shaft, most cellular organelles disappear and are replaced with keratin fibers. We conducted electron microscopic and immunohistochemical studies in hair follicles of the dorsal skin of neonatal rats to investigate the roles of autophagy and proteolysis in this conversion. Autophagy was frequently found in the hair shaft during the keratinization process, especially in the hair cuticle area in the course of a later step of the keratinization. Immunohistochemcal study revealed the striking co-localization of cathepsin B, cathepsin D, cathepsin L, LAMP-1 (a component of lysosomal membrane) and μ-calpain in the external root sheath, keratinizing Henle's layer, keratinizinghair shaft, and primitive sebaceous gland. It suggests the coordination of lysosomal proteases with cytoplasmic enzymes in promotion of the cytoplasmic conversion or terminal differentiation of hair follicle cells.
- 日本組織細胞化学会の論文
著者
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Sakuraba H
Department Of Analytical Biochemistry Meiji Pharmaceutical University
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Ueno T
Toxicological Research Center Nitto Denko Corporation
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Kominami E
Department Of Biochemistry Juntendo University School Of Medicine
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Kominami Eiki
Dep. Of Biochemistry Juntendo Univ. School Of Medicine
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Kawashima Seiichi
Dept. Of Mol. Biol. The Tokyo Metropolitan Inst. Med. Sci
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Sato(kusubata) Kaori
Dept. Of Mol. Biol. The Tokyo Metropolitan Inst. Med. Sci
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Morioka Kiyokazu
Dept. of Clin. Genet., The Tokyo Metropolitan Inst. Med. Sci
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Sato-Kusubata Kaori
Dept. of Mol. Biol., The Tokyo Metropolitan Inst. Med. Sci
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Ueno Takashi
Dept. of Biochemistry, Juntendo University, School of medicine
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Kominami Eiki
Dept. of Biochemistry, Juntendo University, School of medicine
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Sakuraba HItoshi
Dept. of Clin. Genet., The Tokyo Metropolitan Inst. Med. Sci
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Ihara Setsunosuke
Dept. of Biol. ScL, Shimane University, School of Life and Environmental Science
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Sakuraba Hitoshi
Dept. Of Clin. Genet. The Tokyo Metropolitan Inst. Med. Sci
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Morioka Kiyokazu
Dept. Of Clin. Genet. The Tokyo Metropolitan Inst. Med. Sci
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Morioka Kiyokazu
Dept. Gun. Genet. The Tokyo Metropol. Inst. Med. Sci.
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Ihara Setsunosuke
Dept. Of Biol. Scl Shimane University School Of Life And Environmental Science
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Ihara Setsunosuke
Dept. Gun. Genet. The Tokyo Metropol. Inst. Med. Sci.
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Morioka K
The Tokyo Metropolitan Institute Of Medical Science
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Ueno T
Toshiba Corp. Kawasaki‐shi Jpn
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Ueno Takashi
Dept. Of Biochemistry Juntendo University School Of Medicine
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Sakuraba H
Department Of Tumor Immunology And Clinical Genetics Tokyo Metropolitan Institute Of Medical Science
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