Relationship between the Amount of Propranolol Permeating through the Stratum Corneum of Guinea Pig Skin after Application of Propranolol Adhesive Patches and Skin Irritation
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概要
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In the present study we evaluated the relationship between the cumulative amount of propranolol permeating through the stratum corneum and the formation of erythema, a skin irritation reaction, after transdermal application of adhesive patches containing propranolol to the skin of guinea pigs. The intensity of erythema was expressed in terms of a^* values measured with a chromameter. The a^* values increased in guinea pigs after application of the adhesive patches containing 0.4 mg/cm^2 of propranolol to the skin. Since the adhesive patches showed good adhesion to the skin (propranolol content is less than the saturated concentration in the adhesive base) and the cumulative amount of propranolol permeating through the stratum corneum is small, the development of erythema was considered to be mainly due to physical factors such as peeling. Even in adhesive patches containing 0.8 mg/cm^2 or 1.2 mg/cm^2 of propranolol, a^* values increased, although adhesion to the skin is low because of crystallization of propranolol in the adhesive base. On the other hand, in these two adhesive patches, the cumulative amount of propranolol permeating through the stratum corneum increased up to 24 h after application. These findings suggest that the skin irritation reaction is due to propranolol mainly absorbed transdermally, because there is a high correlation between the cumulative amount of propranolol permeating through the stratum corneum and the a^* values (r=0.928).
- 公益社団法人日本薬学会の論文
- 1996-06-15
著者
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Ueno T
Toxicological Research Center Nitto Denko Corporation
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Ueno Takashi
Dept. of Biochemistry, Juntendo University, School of medicine
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KOBAYASHI ICHIRO
Nitto Denko Co.
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Gemba Munekazu
Laboratory Of Functional Morphology Yokohama College Of Pharmacy
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Gemba M
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Gemba Munekazu
Osaka University Of Pharmaceutical Sciences
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Konno Chohachi
Toxicological Research Center Nitto Denko Corporation
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Ueno T
Toshiba Corp. Kawasaki‐shi Jpn
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KOBAYASHI Ichiro
Toxicological Research Center, Nitto Denko Corporation
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HOSAKA Kyoko
Toxicological Research Center, Nitto Denko Corporation
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UENO Takashi
Toxicological Research Center, Nitto Denko Corporation
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MARUO Hiroki
Toxicological Research Center, Nitto Denko Corporation
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KAMIYAMA Masashi
Toxicological Research Center, Nitto Denko Corporation
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Hagiwara K
Toxicological Research Center Nitto Denko Corporation
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Maruo Hiroki
Toxicological Research Center Nitto Denko Corporation
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Kamiyama Masashi
Toxicological Research Center Nitto Denko Corporation
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