PROTECTIVE EFFECT OF A PROTEIN KINASE INHIBITOR ON CELLULAR INJURY INDUCED BY CEPHALORIDINE IN THE PORCINE KIDNEY CELL LINE LLC-PK_1
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概要
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We investigated the effects of a protein kinase C inhibitor and a tyrosine kinase inhibitor on the cellular injury induced by cephaloridine in an established renal epithelial cell line, LLC-PK_1. Cephaloridine increased the leakage of lactate dehydrogenase (LDH) from LLC-PK_1 cells into the medium and also caused an increase in the level of lipid peroxide (index of oxidative stress) in the cells. Treatment of the cells with a hydroxyl radical scavenger, dimethylthiourea (DMTU), inhibited the increases in LDH leakage and lipid peroxidation in LLC-PK_1 cells exposed to cephaloridine. A protein kinase C inhibitor, H-7, and tyrosine kinase inhibitors, genistein and lavendustinA, inhibited the increases in LDH leakage and lipid peroxidation in LLC-PK_1 cells exposed to cephaloridine. These results suggest that a signaling pathway which involves protein kinase C and tyrosine kinase plays a role in the generation of reactive oxygen species in LLC-PK_1 cells damaged by cephaloridine.
- 日本トキシコロジー学会の論文
- 2005-08-29
著者
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Kohda Yuka
Laboratory Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Kawai Yoshiko
Laboratory Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Kohda Yuka
Division Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Kawai Yoshiko
Division Of Pharmacology Osaka University Of Farmaceutical Sciences
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Gemba Munekazu
Laboratory Of Functional Morphology Yokohama College Of Pharmacy
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Gemba M
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Gemba Munekazu
Division Of Pharmacology Osaka University Of Pharmaceutical Sciences
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KODAWARA Takaaki
Division of Pharmacology, Osaka University of Pharmaceutical Sciences
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Kodawara Takaaki
Division Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Gemba Munekazu
Division Of Pharmacology Osaka University Of Farmaceutical Sciences
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