Increases in Urinary Enzyme Excretion in Rats Depleted of Glutathione Inhibited by Scavenger of Oxygen Free Radicals
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概要
- 論文の詳細を見る
Urinary excretion of enzymes by rats was assessed after glutathione (GSH) was depleted by treatment with a mixture of the GSH depletors D, L-buthionine-S, R-sulfoximine (BSO) and diethylmaleate (DEM). Renal GSH was low 2 h after treatment and later returned to the control level. The urinary excretion of γ-glutamyltranspeptidase (γ-GTP) and N-acetyl-β-D-glucosaminidase (NAG) remained high for at least 3 d after the injection of BSO (100 mg/kg) and DEM (0.5 ml/kg), with no effect on the blood urea nitrogen level. N, N'-Dimethylthiourea (DMTU), a scavenger of oxygen free radicals, inhibited this increase in the urinary excretion of γ-GTP. DMTU also inhibited the increase in cisplatin-induced NAG excretion caused by the GSH depletors. These results suggested that the urinary excretion of these enzymes is an index of renal tubular injury caused by shortterm depletion of renal GSH, and that the generation of free radicals may be involved in renal tubular injury during GSH depletion or caused by cisplatin together with GSH depletors.
- 公益社団法人日本薬学会の論文
著者
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KAWAI Yoshiko
Division of Pharmacology, Osaka University of Pharmaceutical Sciences
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GEMBA Munekazu
Division of Pharmacology, Osaka University of Pharmaceutical Sciences
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Kawai Yoshiko
Division Of Pharmacology Osaka University Of Farmaceutical Sciences
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Gemba Munekazu
Division Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Yamaguchi T
Division Of Pharmacology Osaka University Of Pharmaceutical Sciences
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YAMAGUCHI Tatsuya
Division of Pharmacology, Osaka University of Pharmaceutical Sciences
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KAMBARA Katsumi
Division of Pharmacology, Osaka University of Pharmaceutical Sciences
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SUZUKI Atsue
Division of Pharmacology, Osaka University of Pharmaceutical Sciences
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Gemba Munekazu
Division Of Pharmacology Osaka University Of Farmaceutical Sciences
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Suzuki Atsue
Division Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Kambara Katsumi
Division Of Pharmacology Osaka University Of Pharmaceutical Sciences
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