Use of cultured renal epithelial cells for the study of cisplatin toxicity.
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概要
- 論文の詳細を見る
The nephrotoxicity of cisplatin was evaluated in an in vitro system with an established cell line of normal rat kidney, NRK-52E. Leakage of enzymes from the cells into the culture medium increased when they were exposed to 1 μM of cisplatin for 72 hr. The level of lipid peroxides increased in the cells after 48 hr of exposure to cisplatin; the increase was more rapid than the enzyme leakage. This culture system can be used to evaluate drug-induced nephrotoxicity and its mechanism.
- 公益社団法人 日本薬理学会の論文
著者
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Gemba Munekazu
Division Of Pharmacology Osaka University Of Farmaceutical Sciences
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FUKUISHI Nobuyuki
Division of Pharmacology, Osaka University of Pharmaceutical Sciences
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