Relationship between Cisplatin or Nedaplatin-Induced Nephrotoxicity and Renal Accumulation(Pharmacology)
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概要
- 論文の詳細を見る
Nedaplatin is known to exhibit antitumor activity similar to that of cisplatin. However, concerning side effects, nedaplatin causes renal toxicity less frequently than cisplatin. In this study, we compared the incidence of renal toxicity between cisplatin and nedaplatin by investigating the difference in kidney tissue accumulation. Kidney tissue accumulation of cisplatin administered at 3.75mg/kg was similar to that of nedaplatin administered at 24mg/kg. At these doses, the plasma creatinine level and urinary excretion of glucose and N-acetyl-β-D-glucosaminidase (NAG) similarly increased. There was a correlation between kidney accumulation of cisplatin and nedaplatin and the increases in plasma creatinine level and urinary excretion of NAG. Therefore, our results suggest that nedaplatin less frequently causes renal toxicity in comparison to cisplatin due to lower kidney accumulation.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
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Kohda Yuka
Laboratory Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Kawai Yoshiko
Laboratory Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Kawai Yoshiko
Division Of Pharmacology Osaka University Of Farmaceutical Sciences
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Gemba Munekazu
Laboratory Of Functional Morphology Yokohama College Of Pharmacy
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Gemba M
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Gemba Munekazu
Division Of Pharmacology Osaka University Of Pharmaceutical Sciences
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NAKAMURA Masuhisa
Division of Pharmacology, Osaka University of Pharmaceutical Sciences
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TANIUCHI Saburo
Division of Pharmacology, Osaka University of Pharmaceutical Sciences
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OKAHARA Shigeki
Division of Pharmacology, Osaka University of Pharmaceutical Sciences
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Nakamura Masuhisa
Div. Of Pharmacol. Osaka Univ. Pharmaceuti. Sci.
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Nakamura Masuhisa
Division Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Gemba Munekazu
Division Of Pharmacology Osaka University Of Farmaceutical Sciences
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Okahara Shigeki
Div. Of Pharmacol. Osaka Univ. Pharmaceuti. Sci.
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Taniuchi Saburo
Div. Of Pharmacol. Osaka Univ. Pharmaceuti. Sci.
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