Relationship between the Skin Permeation Movement of Propranolol and Skin Inflammatory Reactions
スポンサーリンク
概要
- 論文の詳細を見る
We studied inflammatory reactions induced by dermal application of the β-blocker propranolol (PRL) in ethanol to guinea pigs in orer to elucidate the relation of the reactions with the cumulative PRL permeating amount throgh the stratum corneum or the PRL content in the stripped skin, and to investigate the chemical mediators responsible for the reactions. The cumulative PRL permeating amount through the stratum corneum increased rapidly up to 2 h after dermal application, then increased linearly with time up to 24 h after application. Visual observation revealed formation of erythema and edema at the applied site of PRL, and histopathological examination revealed infiltration of pseudoeosinophiles of dermis and epidermis and degeneration/necrosis of epidermis. In general, it was considered that the duration and the extent of these reactions were dependent on the PRL dosage and application time. It was expected that the cumulative PRL permeating amount through the stratum corneum could be used to predict possible inflammatory reactions during development of transdermal drug delivery systems. On the other hand, contact of PRL with guinea pig skin tissues released histamine, and intradermal injeciton of PRL caused an increase of capillary permeability at the site of application. Also, the inhibitory effects of anti-inflammatory agents (diphenydramine, dexamethasone, indomethacin, cyproheptadine hydrochloride, CV3988 and AA-861) to RRL-induced erythema formation demonstrated that histamine and prostaglandins were responsible for the inflammatory reactions induced by PRL.
- 公益社団法人日本薬学会の論文
- 1998-09-15
著者
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KOBAYASHI ICHIRO
Nitto Denko Co.
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Saeki Yuji
Toxicological Research Center Nitto Denko Corporation
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Gemba Munekazu
Laboratory Of Functional Morphology Yokohama College Of Pharmacy
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Gemba M
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Gemba Munekazu
Osaka University Of Pharmaceutical Sciences
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Konno Chohachi
Toxicological Research Center Nitto Denko Corporation
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KOBAYASHI Ichiro
Toxicological Research Center, Nitto Denko Corporation
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HOSAKA Kyoko
Toxicological Research Center, Nitto Denko Corporation
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MARUO Hiroki
Toxicological Research Center, Nitto Denko Corporation
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KAMIYAMA Masashi
Toxicological Research Center, Nitto Denko Corporation
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Hagiwara K
Toxicological Research Center Nitto Denko Corporation
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Maruo Hiroki
Toxicological Research Center Nitto Denko Corporation
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Kamiyama Masashi
Toxicological Research Center Nitto Denko Corporation
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