Role of Prostaglandin E_2 and Leukotriene B_4 in Skin Reaction Induced by Transdermal Application of Propranolol
スポンサーリンク
概要
- 論文の詳細を見る
Dermal application of propranolol (PRL) induced formation of erythema and edema, and pseudoeosinophil infiltration in epidermis and dermis at the application site in guinea pigs. We investigated the production of prostaglandin E_2 (PCE_2) and leukotriene B_4 (LTB_4) at the application site of PRL and the role of these inflammatory chemical mediators in the occurrence of the skin reactions. PGE_2 was found to be produced at the application site slightly after the accumulation of PRL released from the adhesive bandage in the patch test, and the amount of PGE_2 increased continuously, with a peak value obtained at 24 h after application. The time-course changes resembled those of Δa^* value, the index of erythema formation determined by colorimetric measurement, and edema formation. The production of PGE_2 by dermal application of PRL was suppressed by local pretreatment with dexamethasone or indomethacin. However, no notable production of LTB_4 was observed at the application site of PRL.
- 公益社団法人日本薬学会の論文
- 2000-02-01
著者
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KOBAYASHI ICHIRO
Nitto Denko Co.
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Saeki Yuji
Toxicological Research Center Nitto Denko Corporation
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Gemba Munekazu
Laboratory Of Functional Morphology Yokohama College Of Pharmacy
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Gemba M
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Gemba Munekazu
Osaka University Of Pharmaceutical Sciences
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Konno Chohachi
Toxicological Research Center Nitto Denko Corporation
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KOBAYASHI Ichiro
Toxicological Research Center, Nitto Denko Corporation
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HOSAKA Kyoko
Toxicological Research Center, Nitto Denko Corporation
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MARUO Hiroki
Toxicological Research Center, Nitto Denko Corporation
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KAMIYAMA Masashi
Toxicological Research Center, Nitto Denko Corporation
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Hagiwara K
Toxicological Research Center Nitto Denko Corporation
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Maruo Hiroki
Toxicological Research Center Nitto Denko Corporation
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Kamiyama Masashi
Toxicological Research Center Nitto Denko Corporation
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