SKIN TOXICITY OF PROPRANOLOL IN GUINEA PIGS
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概要
- 論文の詳細を見る
The skin toxicities of propranolol were studied in guinea pigs. In the primary and cumulative skin irritation studies, the skin reactions and the histopathological changes were observed in all animals treated with propranolol, and those tended to increase with the increase of propranolol dosage. The skin reactions increased with the application times of propranolol up to 7 days in the cumulative skin irritation study. In the skin sensitization, the phototoxicity and the skin photosensitization studies, no skin reactions were observed in any animals used in the studies. These results indicate that propranolol caused skin irritation, but was negative for skin sensitization, phototoxicity and skin photosensitization in guinea Pigs.
- 日本トキシコロジー学会の論文
- 1999-05-10
著者
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KOBAYASHI ICHIRO
Nitto Denko Co.
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Saeki Yuji
Toxicological Research Center Nitto Denko Corporation
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Gemba Munekazu
Laboratory Of Functional Morphology Yokohama College Of Pharmacy
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Gemba M
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Gemba Munekazu
Osaka University Of Pharmaceutical Sciences
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Konno Chohachi
Toxicological Research Center Nitto Denko Corporation
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KOBAYASHI Ichiro
Toxicological Research Center, Nitto Denko Corporation
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HOSAKA Kyoko
Toxicological Research Center, Nitto Denko Corporation
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MARUO Hiroki
Toxicological Research Center, Nitto Denko Corporation
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KAMIYAMA Masashi
Toxicological Research Center, Nitto Denko Corporation
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Hagiwara K
Toxicological Research Center Nitto Denko Corporation
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Maruo Hiroki
Toxicological Research Center Nitto Denko Corporation
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Kamiyama Masashi
Toxicological Research Center Nitto Denko Corporation
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