Protein O-Glycosylation Induces Collagen Expression and Contributes to Diabetic Cardiomyopathy in Rat Cardiac Fibroblasts
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概要
- 論文の詳細を見る
Diabetic cardiomyopathy may be accompanied by myocardial fibrosis. We have previously reported that cardiac fibrosis and protein O-glycosylation are elevated in diabetes. In this study, we examined if the hexosamine biosynthesis pathway (HBP) was involved with collagen expression in rat cardiac fibroblasts (RCFs). Long-term glucose load significantly increased type III collagen expression in RCFs, but did not affect the protein O-glycosylation. In addition, glucosamine treatment not only induced expressions of collagen types I and III, but also increased the O-glycosylated protein. These results suggest that O-glycosylation of protein induced by HBP activation modifies collagen expression and contributes to diabetic cardiomyopathy.
- 社団法人 日本薬理学会の論文
- 2009-12-20
著者
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Terasaki Fumio
Third Department of Internal Medicine, Osaka Medical College
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Kono Tatsuji
Third division of internal medicine, Osaka medical college
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Terasaki F
大阪医科大学 第三内科
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Terasaki Fumio
大阪薬科大学 薬物治療学研究室
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Terasaki Fumio
大阪薬科大学 薬物治療学
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Kitaura Yasushi
Third Division Department Of Internal Medicine Osaka Medical College
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Kawakami Yoshihide
Third Division Department Of Internal Medicine Osaka Medical College
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Kawakami Yoshihide
大阪医科大学 第3内科
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Kitaura Yasushi
Third Department Of Internal Medicine Osaka Medical College
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Kitaura Yasushi
Department Of Internal Medicine Iii Osaka Medical College
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Kanzaki Yumiko
Third Department Of Internal Medicine Osaka Medical College
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Terasaki Fumio
Department Of Internal Medicine Iii Osaka Medical College
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Terasaki Fumio
Third Department Of Internal Medicine Osaka Medical College
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Terasaki Fumio
The Third Division Department Of Internal Medicine Osaka Medical College
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Yoshida Kentaro
Department Of Internal Medicine University Of Tsukuba
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KOHDA Yuka
Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences
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Kohda Yuka
Laboratory Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Tanaka Takao
Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences
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Kita Yoshio
Third Department Of Internal Medicine Osaka Medical College
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Yoshida Kentaro
Department Of Cardiology Institute Of Clinical Medicine University Of Tsukuba
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KANEMATSU Miwa
Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences
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Kono Tatsuji
Third Division Department Of Internal Medicine Osaka Medical College
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Kanematsu Miwa
Laboratory Of Pharmacotherapy Osaka University Of Pharmaceutical Sciences
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Kitaura Yasushi
Laboratory Of Pharmacotherapy Osaka University Of Pharmaceutical Sciences
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Kitaura Yasushi
Division Of Cardiology Department Of Internal Medicine Fujita Health University School Of Medicine
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Terasaki. Fumio
The Third Division Department Of Internal Medicine Osaka Medical College
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Kohda Yuka
大阪薬科大学 薬物治療学研究室
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Tanaka Takao
Laboratory Of Pharmacotherapy Osaka University Of Pharmaceutical Sciences
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Kohda Yukinao
Department Of Cardiology University Of Tsukuba Graduate School Of Comprehensive Human Sciences
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Kohda Yuka
Laboratory Of Pharmacotherapy Osaka University Of Pharmaceutical Sciences
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Tanaka Takao
Organization Of Medical Education Osaka Medical College
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