Enhanced Expression of Myeloid-Related Protein Complex (MRP8/14) in Macrophages and Multinucleated Giant Cells in Granulomas of Patients With Active Cardiac Sarcoidosis
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概要
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Background The myeloid-related protein complex (MRP8/14) is expressed in activated human macrophages and reported to be involved in the inflammatory process. The expression of MRP8/14 in patients with cardiac sarcoidosis and idiopathic dilated cardiomyopathy (DCM) was investigated. Methods and Results Serum MRP8/14 levels were measured in 35 patients with sarcoidosis and 23 patients with DCM. Sera from 30 normal volunteers served as controls. Additionally, the expression profiles of MRP8/14 in the myocardium from 12 patients with active cardiac sarcoidosis and 10 DCM patients were examined immunohistochemically. Serum MRP8/14 levels were significantly higher in patients with sarcoidosis than in normal controls [515±549 (SD)ng/ml vs 230±115ng/ml, p=0.0019]. In the sarcoidosis group, serum MRP8/14 levels in patients with definite cardiac involvement (n=10) were significantly higher than in those without (n=25) (974±878ng/ml vs 332±204ng/ml, p=0.0227) and they were also higher than in DCM patients (vs 252±108ng/ml, p=0.0026). Immunohistochemically, MRP8/14 was specifically positive in the cytoplasm of macrophages and multinucleated giant cells in the myocardial granulomas. Conclusions MRP8/14 may be involved in the pathogenesis of sarcoid granulomas. The measurement of serum MRP8/14 levels is useful for the diagnosis of sarcoidosis, and their higher levels suggest the cardiac involvement.
- 2007-09-20
著者
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Fujita Masatoshi
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Okajima Kiyotaka
Department Of Internal Medicine Iii Osaka Medical College
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Otsuka Koji
大阪医科大学 第三内科
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Otsuka Koji
The Third Division Department Of Internal Medicine Osaka Medical College
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Fujita M
Human Health Sciences Graduate School Of Medicine Kyoto University
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Fujita M
School Of Health Sciences Faculty Of Medicine Institute For Frontier Medical Sciences Kyoto Universi
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Terasaki F
大阪医科大学 第三内科
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Terasaki Fumio
大阪薬科大学 薬物治療学研究室
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Terasaki Fumio
大阪薬科大学 薬物治療学
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Otsuka Koji
Department Of Internal Medicine Iii Osaka Medical College
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Kitaura Yasushi
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Kitaura Yasushi
大阪医科大学 3内
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Otsuka Kaoru
Department of Internal Medicine III, Osaka Medical College
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Terasaki Fumio
Department of Internal Medicine III, Osaka Medical College
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Shimomura Hiroaki
Department of Internal Medicine III, Osaka Medical College
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Katashima Takashi
Department of Internal Medicine III, Osaka Medical College
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Ikemoto Masaki
Human Health Sciences, Kyoto University Graduate School of Medicine
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Kita Yoshio
大阪医科大学 第3内科
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Otsuka Kuniaki
Department Of Internal Medicine Iii Osaka Medical College
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Hiramitsu Shinya
Cardiology Hiramitsu Heart Clinic
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Shiraishi Hiroaki
Division Of Cardiology Department Of Internal Medicine Fujita Health University School Of Medicine
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Hiramitsu Shinya
Department Of Internal Medicine And Laboratory Of Medical Engineering And Computer Science Fujita-ga
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Katashima Takashi
Department Of Internal Medicine Iii Osaka Medical College
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Kitaura Yasushi
Third Department Of Medicine Osaka Medical College
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Fujita M
School Of Health Sciences Faculty Of Medicine Kyoto University
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Kitaura Y
Division Of Cardiology Department Of Internal Medicine Fujita Health University School Of Medicine
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Kayama Yosuke
千葉大学 循環病態医科学
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FUJITA MASATOSHI
Otowa Hospital
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Shimomura Hiroaki
3rd dep. of Int. Medicine Osaka Medical College
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Tsukada Bin
Department of Internal Medicine III, Osaka Medical College
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Tsukada Bin
Department Of Internal Medicine Iii Osaka Medical College
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Otsuka Kuniaki
Department Of Medicine Medical Center East Tokyo Women's Medical University
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Terasaki Fumio
Department Of Internal Medicine Iii Osaka Medical College
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Terasaki Fumio
Third Department Of Internal Medicine Osaka Medical College
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Terasaki Fumio
The Third Division Department Of Internal Medicine Osaka Medical College
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Fujita Masatoshi
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Yamada K
Division Of Cardiology Department Of Internal Medicine Fujita Health University School Of Medicine
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Yamada Kazuo
Division Of Circulation And Respiration The Research Institute Of Environmental Medicine Nagoya Univ
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Shimomura Hiroaki
Division Of Cardiology Department Of Internal Medicine Fujita Health University School Of Medicine
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Ikemoto Masaki
Department of Laboratory Science, School of Health Sciences, Faculty of Medicine, Kyoto University
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Shiraishi Hiroaki
Departments Of Pharmacology Fujita Health University
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Yoshida Kentaro
Depatment Of Pediatrics Institute Of Clinical Medicine University Of Tsukuba
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Otsuka Koji
Department Of Electronic Engineering Faculty Of Engineering University Of Tokyo
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Yoshida Kentaro
Department Of Cardiology Institute Of Clinical Medicine University Of Tsukuba
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Ikemoto Masaki
Human Health Sciences Kyoto University Graduate School Of Medicine
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Fujita Masatoshi
Iii Div. Dept Of Intern. Med. Kyoto Univ.
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Ikemoto Masaki
College Of Medical Technology Kyoto University
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Kitaura Yasushi
Department Of Cardiology Institute Of Clinical Medicine University Of Tsukuba
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Hiramitsu Shinya
Division Of Cardiology Department Of Internal Medicine Fujita Health University School Of Medicine
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Terasaki Fumio
Third Division Department Of Internal Medicine Osaka Medical College
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Yoshikawa Katsuhiro
Department Of Cardiology Institute Of Clinical Medicine University Of Tsukuba
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Fujita Masatoshi
Dep. Of Human Health Sciences Graduate School Of Medicine Kyoto Univ.
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Otsuka Kaoru
Department Of Internal Medicine Iii Osaka Medical College
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Terasaki. Fumio
The Third Division Department Of Internal Medicine Osaka Medical College
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Otsuka Koji
Third Division Department Of Internal Medicine Osaka Medical College
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Shimomura Hiroaki
Department Of Chemical Engineering Kyoto University
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Fujita Masatoshi
Department Of Human Health Sciences Division Of Bioinformatics And Chemical Genomics Graduate School
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Fujita Masatoshi
Department Of Human Health Sciences Division Of Bioinformatics And Chemical Genomics Graduate School Of Pharmaceutical Sciences Kyoto University
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Terasaki Fumio
Department Of Cardiology Osaka Medical College
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Otsuka Kaoru
Department of Cardiology, Osaka Medical College, Japan
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