Innovative Preparation of Curcumin for Improved Oral Bioavailability
スポンサーリンク
概要
- 論文の詳細を見る
Curcumin is a polyphenol that is commonly used for its perceived health benefits. However, the absorption efficacy of curcumin is too low to exhibit beneficial effects. We have successfully developed a highly absorptive curcumin dispersed with colloidal nano-particles, and named it THERACURMIN. The absorption efficacy of THERACURMIN was investigated and compared with that of curcumin powder. The area under the blood concentration–time curve (AUC) after the oral administration of THERACURMIN was found to be more than 40-fold higher than that of curcumin powder in rats. Then, healthy human volunteers were administered orally 30 mg of THERACURMIN or curcumin powder. The AUC of THERACURMIN was 27-fold higher than that of curcumin powder. In addition, THERACURMIN exhibited an inhibitory action against alcohol intoxication after drinking in humans, as evidenced by the reduced acetaldehyde concentration of the blood. These findings demonstrate that THERACURMIN shows a much higher bioavailability than currently available preparations. Thus, THERACURMIN may be useful to exert clinical benefits in humans at a lower dosage.
著者
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Hasegawa Koji
Division of Translational Research, National Hospital Organization, Kyoto Medical Center
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Fujita Masatoshi
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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Kudoh Takashi
京都大学 医研究 循環病態
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Kita Toru
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Kobayashi Takashi
Department Of Cardiology Kobe City Medical Center General Hospital
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Kimura Takeshi
神戸市立医療センター中央市民病院 循環器内科
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Kurita Takashi
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
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Morimoto Tatsuya
Division Of Translational Research Kyoto Medical Center
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Kotake Takeshi
国立医薬品食品衛生研究所
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SUNAGAWA Yoichi
Division of Translational Research, Kyoto Medical Center National Hospital Organization
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Wada Hiromichi
Division Of Engineering Graduate School Of Kansai Univ.
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Tamita Koichi
高木循環器科診療所 循環器科
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Kita Toru
National Hospital Organization And Department Of Cardiovascular Medicine Graduate School Of Medicine
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Wada Hiromichi
Division Of Translational Research Kyoto Medical Center National Hospital Organization
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Morimoto Tatsuya
Division Of Translational Research Kyoto Medical Center National Hospital Organization
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Kurita Takashi
The NATIVE
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Kobayashi Takashi
Department Of Cardiology National Cardiovascular Center
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Kuwahara Taishi
Cardiovascular Center Yokosuka Kyosai Hospital
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Kimura Takeshi
Department Of Cardiology Kobe City Medical Center General Hospital
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Fujita Masatoshi
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Kimura Takeshi
Department Of Respiratory Medicine Graduate School Of Medicine Kyoto University
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Kudoh T
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Sunagawa Yoichi
Division Of Translational Research Kyoto Medical Center National Hospital Organization
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Kawamura Teruhisa
Division Of Translational Research Kyoto Medical Center
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KAKEYA Hideaki
Department of Chemistry, Keio University
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Hasegawa Koji
Division Of Translational Research Clinical Research Institute Kyoto Medical Center National Hospita
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Tamita Kouichi
The Department Of Cardiology Kobe General Hospital
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Kimura Takeshi
Department Of Cardiovascular Medicine Kyoto University Hospital
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Tanno Kaoru
Department Of Cardiology Kobe City Medical Center General Hospital
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Sasaki Hiroki
Theravalues Corporation
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Takahashi Kenji
Theravalues Corporation
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Imaizumi Atsushi
Theravalues Corporation
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Fukuda Hiroyuki
Theravalues Corporation
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Hashimoto Tadashi
Theravalues Corporation
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Katanasaka Yasufumi
Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
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Kudoh Takashi
Department Of Nuclear Medicine Kyoto University
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Katagiri Takashi
Department Of Cardiology Kobe City Medical Center General Hospital
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Kita Toru
Department Of Cardiovascualr Medicine Kyoto University Graduate School Of Medicine
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Hashimoto Tadashi
Theravalues Corp.
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Imaizumi Atsushi
Theravalues Corp.
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Kimura Takeshi
Department Of Respiratory Medicine Otsu Red Cross Hospital
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Morimoto Tatsuya
Division Of Molecular Medicine School Of Pharmaceutical Sciences University Of Shizuoka
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Fujita Masatoshi
Department of Human Health Sciences, Graduate School of Medicine, Kyoto University
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Wada Hiromichi
Division of Translational Research, Kyoto Medical Center, National Hospital Organization
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Hasegawa Koji
Division of Translational Research, Kyoto Medical Center, National Hospital Organization
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Sunagawa Yoichi
Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
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