Innovative Preparation of Curcumin for Improved Oral Bioavailability

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概要

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• Curcumin is a polyphenol that is commonly used for its perceived health benefits. However, the absorption efficacy of curcumin is too low to exhibit beneficial effects. We have successfully developed a highly absorptive curcumin dispersed with colloidal nano-particles, and named it THERACURMIN. The absorption efficacy of THERACURMIN was investigated and compared with that of curcumin powder. The area under the blood concentration–time curve (AUC) after the oral administration of THERACURMIN was found to be more than 40-fold higher than that of curcumin powder in rats. Then, healthy human volunteers were administered orally 30 mg of THERACURMIN or curcumin powder. The AUC of THERACURMIN was 27-fold higher than that of curcumin powder. In addition, THERACURMIN exhibited an inhibitory action against alcohol intoxication after drinking in humans, as evidenced by the reduced acetaldehyde concentration of the blood. These findings demonstrate that THERACURMIN shows a much higher bioavailability than currently available preparations. Thus, THERACURMIN may be useful to exert clinical benefits in humans at a lower dosage.

著者

• Hasegawa Koji

  Division of Translational Research, National Hospital Organization, Kyoto Medical Center

• Fujita Masatoshi

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Kudoh Takashi

  京都大学 医研究 循環病態

• Kita Toru

  Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University

• Kobayashi Takashi

  Department Of Cardiology Kobe City Medical Center General Hospital

• Kimura Takeshi

  神戸市立医療センター中央市民病院 循環器内科

• Kurita Takashi

  Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center

• Morimoto Tatsuya

  Division Of Translational Research Kyoto Medical Center

• Kotake Takeshi

  国立医薬品食品衛生研究所

• SUNAGAWA Yoichi

  Division of Translational Research, Kyoto Medical Center National Hospital Organization

• Wada Hiromichi

  Division Of Engineering Graduate School Of Kansai Univ.

• Tamita Koichi

  高木循環器科診療所 循環器科

• Kita Toru

  National Hospital Organization And Department Of Cardiovascular Medicine Graduate School Of Medicine

• Wada Hiromichi

  Division Of Translational Research Kyoto Medical Center National Hospital Organization

• Morimoto Tatsuya

  Division Of Translational Research Kyoto Medical Center National Hospital Organization

• Kurita Takashi

  The NATIVE

• Kobayashi Takashi

  Department Of Cardiology National Cardiovascular Center

• Kuwahara Taishi

  Cardiovascular Center Yokosuka Kyosai Hospital

• Kimura Takeshi

  Department Of Cardiology Kobe City Medical Center General Hospital

• Fujita Masatoshi

  Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University

• Kimura Takeshi

  Department Of Respiratory Medicine Graduate School Of Medicine Kyoto University

• Kudoh T

  Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University

• Sunagawa Yoichi

  Division Of Translational Research Kyoto Medical Center National Hospital Organization

• Kawamura Teruhisa

  Division Of Translational Research Kyoto Medical Center

• KAKEYA Hideaki

  Department of Chemistry, Keio University

• Hasegawa Koji

  Division Of Translational Research Clinical Research Institute Kyoto Medical Center National Hospita

• Tamita Kouichi

  The Department Of Cardiology Kobe General Hospital

• Kimura Takeshi

  Department Of Cardiovascular Medicine Kyoto University Hospital

• Tanno Kaoru

  Department Of Cardiology Kobe City Medical Center General Hospital

• Sasaki Hiroki

  Theravalues Corporation

• Takahashi Kenji

  Theravalues Corporation

• Imaizumi Atsushi

  Theravalues Corporation

• Fukuda Hiroyuki

  Theravalues Corporation

• Hashimoto Tadashi

  Theravalues Corporation

• Katanasaka Yasufumi

  Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka

• Kudoh Takashi

  Department Of Nuclear Medicine Kyoto University

• Katagiri Takashi

  Department Of Cardiology Kobe City Medical Center General Hospital

• Kita Toru

  Department Of Cardiovascualr Medicine Kyoto University Graduate School Of Medicine

• Hashimoto Tadashi

  Theravalues Corp.

• Imaizumi Atsushi

  Theravalues Corp.

• Kimura Takeshi

  Department Of Respiratory Medicine Otsu Red Cross Hospital

• Morimoto Tatsuya

  Division Of Molecular Medicine School Of Pharmaceutical Sciences University Of Shizuoka

• Fujita Masatoshi

  Department of Human Health Sciences, Graduate School of Medicine, Kyoto University

• Wada Hiromichi

  Division of Translational Research, Kyoto Medical Center, National Hospital Organization

• Hasegawa Koji

  Division of Translational Research, Kyoto Medical Center, National Hospital Organization

• Sunagawa Yoichi

  Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka

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