Difference in Myocardial Flow Reserve Between Patients With Dilated Cardiomyopathy and Those With Dilated Phase of Hypertrophic Cardiomyopathy : Evaluation by ^<15>O-Water PET

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概要

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• Background The clinical features of patients with the dilated phase of hypertrophic cardiomyopathy (DHCM) may resemble those of patients with dilated cardiomyopathy (DCM); that is, systolic dysfunction and left ventricular dilatation. Myocardial flow reserve (MFR) is impaired in patients with nonischemic cardiomyopathy, and the reduced MFR may be related to poor prognosis. Several studies report that the mortality rate for patients with DHCM is higher than for DCM, but the difference between these 2 cardiomyopathies is still unclear. The purpose of this study was to assess the MFR of these 2 cardiomyopathies, using ^<15>O-water positron emission tomography (PET) to elucidate their differences. Methods and Results In total 30 patients were investigated: 23 with DCM (Group A) and 7 with DHCM (Group B). All those who were in a stable condition underwent cardiac catheterization. Myocardial blood flow (MBF) at rest and under ATP infusion was measured by ^<15>O-water PET, and the MFR was calculated. There were no significant differences in the hemodynamics of the 2 groups. The mean MFR in DHCM was significantly lower than that in DCM (1.49±0.31 vs 2.62±1.08; p=0.042), whereas MBF at rest did not differ (DCM vs DHCM: 0.66±0.20 vs 0.49±0.05ml-min-1-g-1; NS). The MFR in both Group A and B was significantly decreased com-pared with the normal controls (MFR in normal controls: 5.15±1.64, p=0.00015, 0.00013, respectively). Conclusions These results suggest that impaired vasodilatation (ie, dysfunction of the microcirculation) is more severe in patients with DHCM than in patients with DCM, even though patients' characteristics and hemo-dynamics do not differ.

• 社団法人日本循環器学会の論文
• 2007-05-20

著者

• KITA Toru

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Fujita Masatoshi

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Kimura Takeshi

  Department of Cardiovascular Medicine, Kyoto University Hospital

• Kudoh Takashi

  Department Of Nuclear Medicine Kyoto University Faculty Of Medicine

• 多田村 栄二

  京都大学放射線医学講座画像診断学核医学

• 多田村 栄二

  京都大学 核医画像診断

• 多田村 栄二

  京都大学核医学画像診断学

• 久保 滋人

  京都大学放射線医学講座 核医学画像診断学

• Kobayashi Takashi

  Department Of Cardiology Kobe City Medical Center General Hospital

• Magata Y

  Photon Medical Research Center Hamamatsu University School Of Medicine:molecular Imaging Frontier Re

• Magata Yasuhiro

  京都大学 医学研究科心臓血管外科学

• Magata Yasuhiro

  浜松医科大学附属光量子医学研究センター

• Fujita Masatoshi

  国立病院機構京都医療センター 展開医療研究部

• Fujita M

  Human Health Sciences Graduate School Of Medicine Kyoto University

• Fujita M

  School Of Health Sciences Faculty Of Medicine Institute For Frontier Medical Sciences Kyoto Universi

• Kita Toru

  Department Of Cardiology Kobe City Medical Center General Hospital

• Takenaka Kotoe

  京都大学 院循環器内科

• Tamita Koichi

  高木循環器科診療所 循環器科

• Fujita M

  School Of Health Sciences Faculty Of Medicine Kyoto University

• Magata Y

  Laboratory Of Genome-bio Photonics Photon Medical Research Center Hamamatsu University School Of Med

• Yasuhiro Magata

  Photon Medical Research Center Hamamatsu University School Of Medicine:molecular Imaging Frontier Re

• Tadamura Eiji

  Department of Radiology, Kyoto University Graduate School of Medicine

• Yamamuro Masaki

  Department of Radiology, Kyoto University Graduate School of Medicine

• Kubo Shigeto

  Department of Radiology, Kyoto University Graduate School of Medicine

• Kubo Shigeto

  京都大学 医学研究科循環内科学

• Kubo Shigeto

  Department Of Nuclear Medicine And Diagnostic Imaging Kyoto University Graduate School Of Medicine

• Tadamura Eiji

  京都大学 医学研究科循環器内科学

• Tadamura Eiji

  Department Of Diagnostic Imaging Kyoto University Graduate School Of Medicine

• Tadamura Eiji

  Department Of Nuclear Medicine And Diagnostic Imaging Kyoto University

• Kimura Takshi

  京都大学 院放射線学

• Ohba Muneo

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Kambara Naoshige

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Nohara R

  Division Of Cardiology Kitano Hospital

• FUJITA MASATOSHI

  Otowa Hospital

• Kudou T

  Kyoto Univ.

• MAMEDE Marcelo

  Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University

• Nohara Ryuji

  Division Of Cardiology Kitano Hospital

• Kimura Takeshi

  Department Of Cardiology Kobe City Medical Center General Hospital

• Fujita Masatoshi

  Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University

• Ooba Muneo

  Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine

• Kambara Naoshige

  Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine

• Kanbara Naoshige

  Department Of Cardiovascular Medicine Kyoto University Hospital

• Hosokawa Ryohei

  Division Of Cardiology Kitano Hospital

• Hosokawa Ryohei

  Department Of Cardiovascular Medicine Kyoto University Hospital

• Nohara Ryuji

  Third Division Department Of Internal Medicine Kyoto University Faculty Of Medicine

• Hosokawa Ryohei

  Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine

• Kambara Naoshige

  Department Of Cardiovascular Medicine Kyoto University Hospital

• Miyake Yoshinori

  Department Of Radiology And Nuclear Medicine National Cardiovascular Center

• Kawamoto Takahiro

  Department Of Geriatric Medicine Graduate School Of Medicine Kyoto University

• Yamamuro Masaki

  Department Of Diagnostic Imaging And Nuclear Medicine Kyoto University Graduate School Of Medicine

• Mamede Marcelo

  Department Of Nuclear Medicine And Diagnostic Imaging Kyoto University Graduate School Of Medicine

• Fujita Masatoshi

  Iii Div. Dept Of Intern. Med. Kyoto Univ.

• Nohara Ryuji

  Department Of Cardiology Kitano Hospital Medical Research Institute

• Fujita Masatoshi

  Human Health Sciences Graduate School Of Medicine Kyoto University

• Ohba Muneo

  Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine

• Ooba Muneo

  Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University

• Fujita Masatoshi

  Dep. Of Human Health Sciences Graduate School Of Medicine Kyoto Univ.

• Nohara Ryuji

  Division Of Cardiovascular Medicine Kyoto University

• Mamede Marcelo

  米国

• Hosokawa Ryohei

  Department Of Cardiovascular Medicine School Of Medicine Kyoto University

• Ohba Muneo

  Department Of Cardiovascular Medicine Kushiro Sanjikai Hospital

• Kita Toru

  Division Of Translational Research Kyoto Medical Center National Hospital Organization

• Nohara Ryuji

  Kitano Hospital

• Nohara Ryuji

  Kyoto Univ. Hospital

• Fujita Masatoshi

  Department Of Human Health Sciences Division Of Bioinformatics And Chemical Genomics Graduate School Of Pharmaceutical Sciences Kyoto University

• KIMURA Takeshi

  Department of Applied Chemistry and Molecular Science, Faculty of Engineering, Iwate University

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