Thiamine Prevents Obesity and Obesity-Associated Metabolic Disorders in OLETF Rats

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• We previously found that thiamine mitigates metabolic disorders in spontaneously hypertensive rats, harboring defects in glucose and fatty acid metabolism. Mutation of thiamine transporter gene SLC19A2 is linked to type 2 diabetes mellitus. The current study extends our hypothesis that thiamine intervention may impact metabolic abnormalities in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, exhibiting obesity and metabolic disorders similar to human metabolic syndrome. Male OLETF rats (4 wk old) were given free access to water containing either 0.2% or 0% of thiamine for 21 and 51 wk. At the end of treatment, blood parameters and cardiac functions were analyzed. After sacrifice, organs weights, histological findings, and hepatic pyruvate dehydrogenase (PDH) activity in the liver were evaluated. Thiamine intervention averted obesity and prevented metabolic disorders in OLETF rats which accompanied mitigation of reduced lipid oxidation and increased hepatic PDH activity. Histological evaluation revealed that thiamine alleviated adipocyte hypertrophy, steatosis in the liver, heart, and skeletal muscle, sinusoidal fibrosis with formation of basement membranes (called pseudocapillarization) which accompanied significantly reduced expression of laminin β1 and nidogen-1 mRNA, interstitial fibrosis in the heart and kidney, fatty degeneration in the pancreas, thickening of the basement membrane of the vasculature, and glomerulopathy and mononuclear cell infiltration in the kidney. Cardiac and renal functions were preserved in thiamine treatment. Thiamine has a potential to prevent obesity and metabolic disorders in OLETF rats.

• 財団法人 学会誌刊行センターの論文
• 2010-12-01

著者

• Kitaura Y

  Third Department Of Internal Medicine Osaka Medical College

• Okajima Kiyotaka

  Department Of Internal Medicine Iii Osaka Medical College

• Otsuka Koji

  大阪医科大学 第三内科

• Otsuka Koji

  The Third Division Department Of Internal Medicine Osaka Medical College

• Kitaura Y

  Third Department Of Medicine Osaka Medical College

• Terasaki Fumio

  Third Department of Internal Medicine, Osaka Medical College

• Soyama Akiko

  Third division of internal medicine, Osaka medical college

• Kono Tatsuji

  Third division of internal medicine, Osaka medical college

• Terasaki F

  大阪医科大学 第三内科

• Terasaki Fumio

  大阪薬科大学 薬物治療学研究室

• Terasaki Fumio

  大阪薬科大学 薬物治療学

• Kitaura Yasushi

  Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine

• Soyama Akiko

  Third Department Of Internal Medicine Osaka Medical College

• Kitaura Yasushi

  Third Division Department Of Internal Medicine Osaka Medical College

• Fujioka Shigekazu

  大阪医科大学 内科学第3

• Otsuka Kaoru

  Third Division, Department of Internal Medicine, Osaka Medical College

• Kita Yoshio

  大阪医科大学 第3内科

• Otsuka Kuniaki

  Department Of Internal Medicine Iii Osaka Medical College

• Kawakami Yoshihide

  Third Division Department Of Internal Medicine Osaka Medical College

• Kawakami Yoshihide

  大阪医科大学 第3内科

• Kitaura Yasushi

  Third Department Of Internal Medicine Osaka Medical College

• Kitaura Yasushi

  Department Of Internal Medicine Iii Osaka Medical College

• Yamashita Kentaro

  Cardiovascular Center Nagoya Daini Red Cross Hospital

• Kono Tatsuji

  Third Division Of Internal Medicine Osaka Medical College

• Fujita Shuichi

  Department Of Internal Medicine Iii Osaka Medical College

• Kanzaki Yumiko

  Third Department Of Internal Medicine Osaka Medical College

• Otsuka Kuniaki

  Department Of Internal Medicine Tokyo Women's Medical University Medical Center East

• Terasaki Fumio

  Department Of Internal Medicine Iii Osaka Medical College

• Terasaki Fumio

  Third Department Of Internal Medicine Osaka Medical College

• Terasaki Fumio

  The Third Division Department Of Internal Medicine Osaka Medical College

• Yoshida Kentaro

  Department Of Internal Medicine University Of Tsukuba

• Kihara Yasuki

  Division Of Cardiology Kobe General Hospital

• KOHDA Yuka

  Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences

• Kohda Yuka

  Laboratory Of Pharmacology Osaka University Of Pharmaceutical Sciences

• Yamane Kazuhiko

  Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences

• Tanaka Takao

  Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences

• Soyama Akiko

  Third Division Department Of Internal Medicine Osaka Medical College

• Yoshida Kentaro

  Depatment Of Pediatrics Institute Of Clinical Medicine University Of Tsukuba

• Yoshida Kentaro

  Department Of Cardiology Institute Of Clinical Medicine University Of Tsukuba

• Usui Kazuya

  Laboratory of Biology, Hokkaido University of Education

• YASUI Kota

  Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences

• FUJITA Shuichi

  Third Division, Department of Internal Medicine, Osaka Medical College

• MANABE Miki

  Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences

• Kono Tatsuji

  Third Division Department Of Internal Medicine Osaka Medical College

• Otsuka Kaoru

  Third Div. Dep. Of Internal Medicine Osaka Medical Coll.

• Fujita Shuichi

  Third Div. Dep. Of Internal Medicine Osaka Medical Coll.

• Terasaki Fumio

  Third Division Department Of Internal Medicine Osaka Medical College

• Usui Kazuya

  Laboratory Of Pharmacotherapy Osaka University Of Pharmaceutical Sciences

• Yamane Kazuhiko

  Laboratory Of Pharmacotherapy Osaka University Of Pharmaceutical Sciences

• Kitaura Yasushi

  Laboratory Of Pharmacotherapy Osaka University Of Pharmaceutical Sciences

• Kitaura Yasushi

  Division Of Cardiology Department Of Internal Medicine Fujita Health University School Of Medicine

• Manabe Miki

  Laboratory Of Pharmacotherapy Osaka University Of Pharmaceutical Sciences

• TANAKA Takao

  Organization of Medical Education, Osaka Medical College

• Terasaki. Fumio

  The Third Division Department Of Internal Medicine Osaka Medical College

• Otsuka Koji

  Third Division Department Of Internal Medicine Osaka Medical College

• Kohda Yuka

  大阪薬科大学 薬物治療学研究室

• Tanaka Takao

  Laboratory Of Pharmacotherapy Osaka University Of Pharmaceutical Sciences

• Kohda Yukinao

  Department Of Cardiology University Of Tsukuba Graduate School Of Comprehensive Human Sciences

• Kohda Yuka

  Laboratory Of Pharmacotherapy Osaka University Of Pharmaceutical Sciences

• Tanaka Takao

  Organization Of Medical Education Osaka Medical College

• Soyama Akiko

  Third Division, Department of Internal Medicine, Osaka Medical College

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