Thiamine Prevents Obesity and Obesity-Associated Metabolic Disorders in OLETF Rats
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概要
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We previously found that thiamine mitigates metabolic disorders in spontaneously hypertensive rats, harboring defects in glucose and fatty acid metabolism. Mutation of thiamine transporter gene SLC19A2 is linked to type 2 diabetes mellitus. The current study extends our hypothesis that thiamine intervention may impact metabolic abnormalities in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, exhibiting obesity and metabolic disorders similar to human metabolic syndrome. Male OLETF rats (4 wk old) were given free access to water containing either 0.2% or 0% of thiamine for 21 and 51 wk. At the end of treatment, blood parameters and cardiac functions were analyzed. After sacrifice, organs weights, histological findings, and hepatic pyruvate dehydrogenase (PDH) activity in the liver were evaluated. Thiamine intervention averted obesity and prevented metabolic disorders in OLETF rats which accompanied mitigation of reduced lipid oxidation and increased hepatic PDH activity. Histological evaluation revealed that thiamine alleviated adipocyte hypertrophy, steatosis in the liver, heart, and skeletal muscle, sinusoidal fibrosis with formation of basement membranes (called pseudocapillarization) which accompanied significantly reduced expression of laminin β1 and nidogen-1 mRNA, interstitial fibrosis in the heart and kidney, fatty degeneration in the pancreas, thickening of the basement membrane of the vasculature, and glomerulopathy and mononuclear cell infiltration in the kidney. Cardiac and renal functions were preserved in thiamine treatment. Thiamine has a potential to prevent obesity and metabolic disorders in OLETF rats.
- 財団法人 学会誌刊行センターの論文
著者
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Terasaki Fumio
Third Department of Internal Medicine, Osaka Medical College
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Soyama Akiko
Third division of internal medicine, Osaka medical college
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Kono Tatsuji
Third division of internal medicine, Osaka medical college
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Terasaki F
大阪医科大学 第三内科
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Terasaki Fumio
大阪薬科大学 薬物治療学
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Otsuka Kaoru
Third Division, Department of Internal Medicine, Osaka Medical College
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Terasaki Fumio
Department Of Internal Medicine Iii Osaka Medical College
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KOHDA Yuka
Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences
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Yamane Kazuhiko
Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences
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Tanaka Takao
Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences
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Usui Kazuya
Laboratory of Biology, Hokkaido University of Education
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YASUI Kota
Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences
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FUJITA Shuichi
Third Division, Department of Internal Medicine, Osaka Medical College
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MANABE Miki
Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences
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