Amelioration by CAMP of Cephaloridine-Induced Injury in the Porcine Kidney Cell Line LLC-PK_1
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概要
- 論文の詳細を見る
We investigated the effects of a phosphodiesterase inhibitor and dibutyryl CAMP (dBcAMP) on the cell injury induced by cephaloridine (CER) in an established renal epithelial cell LLC-PK<SUB>1</SUB>. CER increased the leakage of lactate dehydrogenase (LDH) from LLC-PK<SUB>1</SUB> cells to the medium and the level of lipid peroxidation in the cells. 3-Isobutyl-1-methylxanthine, a phosphodiesterase inhibitor, increased CAMP content in LLC-PK<SUB>1</SUB> cells and ameliorated the increase in LDH Ieakage induced by CER. dBcAMP reduced the cell injury induced by CER. Our results suggest that a signalling pathway of CAMP protects against CER-induced renal cell injury, which is probably due to generation of oxygen radicals.
- 社団法人 日本薬理学会の論文
- 1996-09-01
著者
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Kawai Yoshiko
Division Of Pharmacology Osaka University Of Farmaceutical Sciences
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Kawai Yoshiko
Division Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Gemba Munekazu
Division Of Pharmacology Osaka University Of Farmaceutical Sciences
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