Contribution of Chloride Channel Conductance to the Regulation of Resting Membrane Potential in Chondrocytes
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概要
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The contribution of Cl− conductance relative to that of K+ in the regulation of membrane potential was examined using OUMS-27 cells, a model cell-line of human chondrocytes. Application of 100 μM niflumic acid (NFA) and other anion-channel blockers induced significant membrane hyperpolarization. The NFA-sensitive membrane current under voltage-clamp was predominantly Cl− current. Application of NFA induced small but significant increase in intracellular Ca2+ concentration ([Ca2+]i) and markedly enhanced the late component of [Ca2+]i rise induced by 1 μM histamine. In conclusion, Cl− conductance substantially contributes to the regulation of resting membrane potential and [Ca2+]i in OUMS-27 cells.
- 社団法人 日本薬理学会の論文
著者
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OHYA Susumu
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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YAMAMURA Hisao
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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IMAIZUMI Yuji
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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FUJII Masato
Department of Otolaryngology, School of Medicine, Keio University
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Funabashi Kenji
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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Fujii Masato
Department Of Life Science Graduate School Of Science And Technology Niigata University
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Ohya Susumu
Department Of Molecular & Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoy
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Imaizumi Yuji
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Funabashi Kenji
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Fujii Masato
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Yamamura Hisao
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Yamamura Hisao
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Funabashi Kenji
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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Ohya Susumu
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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Fujii Masato
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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Yamamura Hisao
Department of Molecular & Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Yamamura Hisao
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
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