Voltage-Dependent Ca^<2+>-Channel Block by Openers of Intermediate and Small Conductance Ca^<2+>-Activated K^+ Channels in Urinary Bladder Smooth Muscle Cells
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概要
- 論文の詳細を見る
We examined effects of small and intermediate Ca2+-activated K+ (SK and IK) channel openers, DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) and NS309 (3-oxime-6,7-dichloro-1H-indole-2,3-dione), on L-type Ca2+ channel current (ICa) that was measured in smooth muscle cells isolated from mouse urinary bladder under whole cell voltage-clamp. The ICa was concentration-dependently inhibited by DCEBIO and NS309; half inhibition was obtained at 71.6 and 10.6 μM, respectively. The specificity of NS309 to the IK channel over the Ca2+ channel appears to be high and higher than that of DCEBIO. DCEBIO and even NS309 may, however, substantially block Ca2+ channels when used as SK channel openers.
- 社団法人 日本薬理学会の論文
- 2006-03-20
著者
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OHYA Susumu
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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YAMAMURA Hisao
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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IMAIZUMI Yuji
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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Ishii Yoko
大分医科大学臨床薬理学
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Ohya Susumu
Dep. Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City U
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Ohya Susumu
Department Of Molecular & Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoy
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Imaizumi Y
Dep. Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City U
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Imaizumi Yuji
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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MORIMURA Kozo
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoy
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Morimura Kozo
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Yamamura Hisao
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Yamamura Hisao
Department Of Molecular And Cellular Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya
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Yamamura H
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Ishii Yatsuka
Department Of Clinical Pharmacology And Therapeutics Oita Medical University
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Yamamura Hisao
Department of Molecular & Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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