EFFECT OF 4-AMINOPYRIDINE ON POTASSIUM PERMEABILITY OF CANINE TRACHEAL SMOOTH MUSCLE CELL MEMBRANE
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概要
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Effect of 4-aminopyridine (4-AP) on the potassium permeability of the cell membrane of canine tracheal smooth muscle was investigated using <SUP>86</SUP>Rb-efflux. The <SUP>86</SUP>Rb-efflux from the strip was remarkably increased by 20 mM 4-AP in normal physiological solution in the presence of 1 μM atropine. In high potassium and chloride deficient solution, 4-AP (0.3-20 mM) decreased the rate of <SUP>86</SUP>Rb-efflux in a dosedependent manner. This finding indicates that 4-AP interacted with a single class of site of action in depolarized tracheal smooth muscle. The maximum decrease in <SUP>86</SUP>Rb-efflux and the inhibitory dissociation constant of 4-AP were 42.3% and 1.49 mM, respectively. 4-AP had an inhibitory effect on the K permeability of the cell membrane of canine tracheal smooth muscle, and it seemed to interact with the same site of action of tetraethylammonium (TEA), but was less effective than TEA.
- 社団法人 日本薬理学会の論文
著者
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Imaizumi Yuji
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Watanabe Minoru
Department Of Molecular And Cellular Pharmacology Nagoya City University
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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