DESENSITIZATION OF GUINEA PIG TRACHEAL MUSCLE PREPARATION TO BETA-ADRENERGIC STIMULANTS BY A PRECEDING EXPOSURE TO A HIGH DOSE OF CATECHOLAMINES
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概要
- 論文の詳細を見る
When a given concentration of a catecholamine was applied to guinea pig tracheal preparation contracted by 20 μM histamine or by 30 mM-K<SUP>+</SUP>-Tyrodes solution, constant relaxations were observed, if the relaxation was submaximal. When a high concentration of catecholamine, 200 times the ED50, was once applied, subsequent responses to beta-stimulants (ED80) was reduced by about 30-40 %, in spite of repeated washings. The response was gradually recovered in 2 hr. Thus 45 μM epinephrine and 1 μM isoproterenol could cause desensitization to 0.65 μM epinephrine and 0.03 μM isoproterenol, respectively. Epinephrine and isoproterenol could cause desensitization to isoprophenamine, a non-catechol beta-stimulant. Epinephrine did not affect the response to cyclic AMP, dibutyryl cyclic AMP, aminophylline and prostaglandin E<SUB>1</SUB>. This desensitization was not affected by phentolamine, normetanephrine nor by Ca<SUP>2-</SUP> deprivation from the bathing solution. The mechanisms of the desensitization may relate to some step(s) between the receptor-drug interaction and cyclic AMP accumulation in the process of tracheal muscle relaxation induced by beta-stimulants.
- 社団法人 日本薬理学会の論文
著者
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Watanabe Minoru
Department Of Molecular And Cellular Pharmacology Nagoya City University
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Ohno Yasuo
Department Of Electrical And Electronic Engineering The University Of Tokushima
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Ohno Yasuo
Department Of Electric And Electronic Engineering The University Of Tokushima
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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WATANABE Minoru
Department of Toxicology and Pharmacology, Research Institute for Chemical Hazards, Faculty of Pharmaceutical Sciences, University of Tokyo
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OHNO Yasuo
Department of Toxicology and Pharmacology, Research Institute for Chemical Hazards, Faculty of Pharmaceutical Sciences, University of Tokyo
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KASUYA Yutaka
Department of Toxicology and Pharmacology, Research Institute for Chemical Hazards, Faculty of Pharmaceutical Sciences, University of Tokyo
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