RHYTHMIC CONTRACTIONS INDUCED BY VAGOTOMY IN THE FUNDUS OF RAT STOMACH
スポンサーリンク
概要
- 論文の詳細を見る
Continuous rhythmic contractions were observed in longitudinal muscle strips of fundus obtained from the chronically vagotomized rat stomach. These vagotomy-induced rhythmic contractions (VRC) were not blocked either by tetrodotoxin (3 × 10<SUP>-6</SUP> M) or atropine (3 × 10<SUP>-7</SUP> M), indicating that the VRC was myogenic in origin. It was also found that the VRC had the following characteristics. 1) The VRC was blocked either by 10<SUP>-5</SUP> M D600 or by Ca<SUP>2+</SUP> deprivation from the medium. 2) On replacement of Na<SUP>+</SUP> with sucrose or of K<SUP>+</SUP> with Na<SUP>+</SUP>, the tone of fundus strips was concomitantly elevated with the cessation of the VRC. 3) 10<SUP>-5</SUP> M ouabain blocked the VRC. 4) The VRC was blocked by cooling. 5) The VRC disappeared under anoxic conditions. Based on these results possible mechanisms of the VRC are discussed in relation to an energy dependent activity of the cell membrane.
- 社団法人 日本薬理学会の論文
著者
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Kamata Katsuo
Department Of Pharmacology School Of Pharmacy Hoshi University:department Of Chemical Pharmacology F
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Watanabe Minoru
Department Of Molecular And Cellular Pharmacology Nagoya City University
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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WATANABE Minoru
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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KAMATA Katsuo
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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KAMATA Katsuo
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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