Effects of Chronic Administration of Fruit Extract (Citrus unshiu M_<ARC>) on Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats(Pharmacology)
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概要
- 論文の詳細を見る
We investigated the effects of chronic administration of fruit extract (Citrus unshiu M_<ARC>) on the endothelial dysfunction seen in aortae from streptozotocin (STZ)-induced diabetic rats. A ten-week administration of this fruit extract preserved acetylcholine (ACh)-induced endothelium-dependent relaxation, but not sodium nitroprusside (SNP)-induced endothelium-independent relaxation, in the diabetic aorta. In age-matched control rats, chronic administration of the fruit extract had no influence on the ACh- or SNP-induced aortic relaxation. The increased total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride levels seen in STZ-induced diabetic rats were not normalized by fruit-extract treatment. These results suggest that Citrus unshiu M_<ARC> extract preserves endothelial function in the aorta in STZ-induced diabetic rats without lowering plasma cholesterol. This beneficial effect may be due to this extract protecting of nitric oxide against inactivation by oxygen free radicals.
- 公益社団法人日本薬学会の論文
- 2005-02-01
著者
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MATSUMOTO Takayuki
Departments of Laboratory Medicine, Ohashi and Omori Hospitals, School of Medicine, Toho University
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Sugiura Minoru
Laboratory Of Post-harvest Physiology Department Of Citrus Research Okitsu National Institute Of Fru
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KAMATA Katsuo
Department of Pharmacology, School of Pharmacy, Hoshi University
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Kamata K
Dep. Of Physiology And Morphology Inst. Of Medicinal Chemistry Hoshi Univ.
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Kamata Katsuo
Department Of Pharmacology School Of Pharmacy Hoshi University:department Of Chemical Pharmacology F
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KOBAYASHI Tsuneo
Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
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KANIE Noriyasu
Department of Physiology and Morphology, Institute of Medicinal Chemistry
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ODA Shu-ichi
Department of Physiology and Morphology, Institute of Medicinal Chemistry
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KANEDA Akihito
Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
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Oda Shu-ichi
Department Of Physiology And Morphology Institute Of Medicinal Chemistry
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Kaneda Akihito
Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University
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Kanie Noriyasu
Department Of Physiology And Morphology Institute Of Medicinal Chemistry
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Matsumoto Takayuki
Department Of Gastroenterology Osaka City University Graduate Medical School
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Matsumoto Takayuki
Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University
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Kobayashi Tsuneo
Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University
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Matsumoto Takayuki
Department Of Gastroenterology And Hepatology Institute Of Clinical Medicine Graduate School Of Comp
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Kobayashi Tsuneo
Department Of Physics School Of Medicine Fukushima Medical University
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Matsumoto Takayuki
Department Of Electronics Information And Communication Engineering Waseda University
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KAMATA Katsuo
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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KOBAYASHI TSUNEO
Department of Natural Sciences (Physics), School of Medicine, Fukushima Medical University
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KOBAYASHI Tsuneo
Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo Noko University
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