Vasodilator Effect of Cassiarin A, a Novel Antiplasmodial Alkaloid from Cassia siamea, in Rat Isolated Mesenteric Artery

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概要

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• The aim of this study was to investigate the vasorelaxant effect induced by cassiarin A, a novel antiplasmodial alkaloid from Cassia siamea, in rings cut from rat superior mesenteric arteries. In rings precontracted with phenylephrine, cassiarin A induced a concentration-dependent relaxation. This relaxation was attenuated: 1) after removal of the endothelium or after pretreatment of rings with 100 μM of NG-nitro-L-arginine (nitric oxide synthase inhibitor) or 10 μM of 1H-[1,2,4]oxadiazolo[4,3-a]-quinoxalin-1-one (guanylyl cyclase inhibitor), but not after pretreatment with 10 μM of indomethacin (cyclooxygenase inhibitor); and 2) after pretreatment of preparations with either a nonselective or selective inhibitor of large-conductance Ca2+-activated K+ (BKCa) channels [1 mM of tetraethylammonium or 100 nM of iberiotoxin, respectively]. The cassiarin A-induced relaxation was also attenuated by these BKCa inhibitors in endothelium-denuded preparations. The cassiarin Ainduced relaxation was not altered by treatment with the ATP-sensitive K+-channel inhibitor glibenclamide (10 μM) or with the voltage-dependent K+-channel inhibitor 4-aminopyridine (1 mM). In isolated mesenteric artery rings, cassiarin A tended to increase nitric oxide (NO) levels. These results suggest that in the rat mesenteric artery, cassiarin A-induced relaxation may be mediated by endothelial NO and may occur partly via BKCa-channel activation.

著者

• MATSUMOTO Takayuki

  Departments of Laboratory Medicine, Ohashi and Omori Hospitals, School of Medicine, Toho University

• Morita Hiroshi

  Faculty of Pharmaceutical Sciences, Hoshi University

• Hirasawa Yusuke

  Faculty of Pharmaceutical Sciences, Hoshi University

• HONDA Toshio

  Faculty of Pharmaceutical Sciences, Hoshi University

• Hirasawa Yusuke

  Faculty Of Pharmaceutical Sciences Hoshi University

• Ishida Keiko

  Department of Bioresources Chemistry, Chiba University

• Honda Toshio

  Faculty Of Pharmaceutical Sciences Hoshi University

• KAMATA Katsuo

  Department of Pharmacology, School of Pharmacy, Hoshi University

• Kamata Katsuo

  Department Of Pharmacology School Of Pharmacy Hoshi University:department Of Chemical Pharmacology F

• Ishida Keiko

  Department Of Bioresources Chemistry Chiba University

• KOBAYASHI Tsuneo

  Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University

• Matsumoto Takayuki

  Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University

• Ishida Keiko

  Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University

• Morita Hiroshi

  Faculty Of Pharmaceutical Sciences Hoshi University:laboratory Of Pharmacotherapeutics Showa Pharmac

• Kobayashi Tsuneo

  Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University

• Matsumoto Takayuki

  Department Of Gastroenterology And Hepatology Institute Of Clinical Medicine Graduate School Of Comp

• Morita Hiroshi

  Faculty Of Environment Engineering The University Of Kitakyushu

• Kobayashi Tsuneo

  Department Of Physics School Of Medicine Fukushima Medical University

• Matsumoto Takayuki

  Department Of Electronics Information And Communication Engineering Waseda University

• KAMATA Katsuo

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University

• KOBAYASHI TSUNEO

  Department of Natural Sciences (Physics), School of Medicine, Fukushima Medical University

• Ishida Keiko

  Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University

• Hirasawa Yusuke

  Faculty of Pharmaceutical Science, Hoshi University

• KOBAYASHI Tsuneo

  Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo Noko University

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