Construction of an Enantiomerically Pure 6-Substituted 3,5-syn-Dihydroxyhexanoic Acid System by an Enantioselective Deprotonation Strategy : Formal Synthesis of an Antiobesity Agent, (-)-Tetrahydrolipstatin
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概要
- 論文の詳細を見る
Preparation of 6-substituted 4-hydroxytetrahydro-2H-pyran-2-one (12), a key intermediate for the synthesis of (-)-tetrahydrolipstatin, was achieved in an optically pure form by employing an enantioselective deprotonation reaction of the prochiral bicyclic derivative (5) as a key step.
- 公益社団法人日本薬学会の論文
- 2000-10-01
著者
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HONDA Toshio
Faculty of Pharmaceutical Sciences, Hoshi University
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Ono Satoko
Faculty Of Pharmaceutical Sciences Hoshi University
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ENDO Katsunori
Faculty of Pharmaceutical Sciences, Hoshi University
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Honda Toshio
Faculty Of Pharmaceutical Sciences Hoshi University
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Endo K
Faculty Of Pharmaceutical Sciences Hoshi University
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