STUDIES ON THE HYPOTENSIVE EFFECTS OF PLATELET ACTIVATING FACTOR (PAF, 1-o-ALKYL-2-ACETYL-sn-GLYCERYL-3-PHOSPHORYLCHOLINE) IN RATS, GUINEA PIGS, RABBITS, AND DOGS
スポンサーリンク
概要
- 論文の詳細を見る
Platelet activating factor (PAF) showed profound and long-lasting hypotensive effects in normotensive and spontaneously hypertensive rats, guinea pigs, rabbits and dogs. Sensitivity to PAF was different among the animal species. The magnitude and duration of the hypotensive effect was dose-dependent. Pharmacological studies suggested that the hypotensive action was unlikely to be caused by the actions on the central or autonomic nervous systems but seemed to be mainly due to some direct action(s) on the peripheral blood vessels.
- 公益社団法人日本薬学会の論文
著者
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Tanaka Sakuya
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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MASUDA YUKINORI
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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Masuda Yukinori
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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