Effect of Cilnidipine on L- and T-type Calcium Currents in Guinea Pig Ventricle and Action Potential in Rabbit Sinoatrial Node
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概要
- 論文の詳細を見る
Cilnidipine, a dihydropyridine Ca2+ channel antagonist, is known to have inhibitory effects on both L- and N-type Ca2+ currents. In the present study, we examined the effect of cilnidipine on myocardial L- and T-type Ca2+ currents and sinoatrial node action potential configuration. In voltage clamped guinea pig ventricular myocytes, cilnidipine concentration-dependently decreased L- and T-type Ca2+ currents. In rabbit sinoatrial node tissue, cilnidipine increased cycle length through reduction of phase 4 depolarization slope. In conclusion, cilnidipine has inhibitory effects on T-type Ca2+ current, which may contribute to its negative chronotropic potency.
- 公益社団法人 日本薬理学会の論文
著者
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MASUMIYA Haruko
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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YAMAGISHI Reiko
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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Masumiya Haruko
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Yamagishi Reiko
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Takeda Kentaro
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Toho University
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Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
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Takeda Kentaro
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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