Effect of NIP-142 on Potassium Channel α-Subunits Kv1.5, Kv4.2 and Kv4.3, and Mouse Atrial Repolarization
スポンサーリンク
概要
- 論文の詳細を見る
Effects of NIP-142, a benzopyran compound which terminates experimental atrial arrhythmia, on potassium channel α-subunits and mouse atrial repolarization were examined. NIP-142 concentration-dependently blocked the outward current through potassium channel α subunits Kv1.5, Kv4.2 and Kv4.3 expressed in Xenopus oocytes. In isolated mouse atrial myocardia, NIP-142 prolonged the action potential duration and effective refractory period, and increased the contractile force. These results suggest that NIP-142 blocks the potassium channels underlying the transient and sustained outward currents, which may contribute to its antiarrhythmic activity.
著者
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Kawamura Taro
Department Of Dermatology Faculty Of Medicine University Of Tokyo
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Masuda Hiroyuki
Department Of Applied Chemistry Faculty Of Engineering Gunma University
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Hamaguchi Shogo
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Yoshio
Department Of Applied Chemistry Faculty Of Engineering Yokohama National University
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Namekata Iyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Toho University
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Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
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Iida-Tanaka Naoko
Department of Biochemistry, Teikyo University School of Medicine
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TANAKA Hikaru
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences
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Namekata Iyuki
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences
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Masuda Hiroyuki
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences
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Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
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Kawamura Taro
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences
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Takahara Akira
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences
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Iida-Tanaka Naoko
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences
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