Role of BK Channels in Testosterone-Induced Relaxation of the Aorta in Spontaneously Hypertensive Rats(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
The previous data indicated that the testosterone (Tes)-induced relaxation of thoracic aorta is greater in spontaneously hypertensive rats (SHR) than in normotensive rats (Wistar-Kyoto rats; WKY) and that there were differences between SHR and WKY in the functions of K_<ATP>, K_V, and K_<Ca> channels. The present study was carried out to ascertain the mechanisms of the Tes-induced relaxation. Indomethacin (30 μM) pretreatment suppressed the Tes-induced relaxation. Following noradrenalin (NA)-induced vasoconstriction, the relaxation induced by Tes was significantly attenuated by endothelium removal in SHR (not in WKY), but the dilatory effect of Tes following KCl-induced vasoconstriction was not attenuated by endothelium removal. After tetraethylammonium (K_<Ca> channel inhibitor) or iberiotoxin (large conductance, Ca^<2+> activated BK channel inhibitor) pretreatment, the Tes-induced relaxation was attenuated in SHR, but not in WKY. This attenuation in SHR was not observed after endothelium removal. The above results suggest that the relaxation induced by Tes following NA-induced vasoconstriction in SHR results from hyperpolarization due to BK channel opening.
- 公益社団法人日本薬学会の論文
- 2007-08-01
著者
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Unemoto Tamao
Department of Pharmacy, Nippon Medical School, Tama-Nagayama Hospital
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KOIKE Katsuo
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Koike Katsuo
東京薬科大学 内分泌分子薬理学
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Koike K
Toho Univ. School Of Pharmaceutical Sci. Chiba Jpn
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Yoshio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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TAMURA Kazuhiro
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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KOGO Hiroshi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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Unemoto Tamao
Department Of Endocrine Pharmacology Tokyo University Of Pharmacy And Life Science
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KOIKE Katsuo
Toho University School of Pharmaceutical Sciences
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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Koike K
Toho Univ. Chiba Jpn
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Tanaka Yoshio
Dep. Of Chemical Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Toyoda Yoshihiro
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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Kogo Hiroshi
Department Of Endocrine Pharmacology Tokyo University Of Pharmacy And Life Science
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MATSUSHITA Mayumi
Department of Endocrine Pharmacology, Tokyo University of Pharmacy and Life Science
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Matsushita Mayumi
Department Of Endocrine Pharmacology Tokyo University Of Pharmacy And Life Science
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Tanaka Yoshio
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tamura Kazuhiro
Department Of Endocrine Pharmacology Tokyo University Of Pharmacy And Life Science
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Tanaka Yoshio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Tanaka Yoshio
Department Of Applied Chemistry Faculty Of Engineering Yokohama National University
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TAMURA Kazuhiro
Department of Endocrine and Neural Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan
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