Effect of Etidronate on Aortic Calcification and Bone Metabolism in Calcitoriol-Treated Rats With Subtotal Nephrectomy
スポンサーリンク
概要
- 論文の詳細を見る
The present study was undertaken to determine the effects of etidronate (ED) on calcitriol-induced aortic calcification and bone metabolism in rats with renal failure. Severe aortic calcification was induced by treatment with calcitriol for 3 weeks in rats in which 5/6 of the kidneys were removed (SNx group). Treatment of ED (10 mg/kg) together with calcitriol after subtotal nephrectomy (SNx) significantly inhibited thoracic and abdominal aortic calcification 3 weeks after the operation; however, ED (2 mg/kg) was ineffective. The serum levels of osteocalcin and pyridinoline decreased in ED (10 mg/kg) treated-renal failure rats compared with SNx rats. Total bone mineral density (BMD) in the SNx group was lower than that in the sham group, in which animals were treated with calcitriol after a sham operation. The total BMD value in the ED (10 mg/kg)-treated group was similar to that in the SNx group, whereas the levels of cancellous BMD were low in the ED (10 mg/kg)-treated rats. Our data show that ED at a dosage that suppresses bone metabolism markedly inhibits vascular calcification in rats with renal failure.
- 社団法人 日本薬理学会の論文
- 2005-09-20
著者
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SUZUKI Yusuke
Department of Electrical Engineering and Computer Science, Nagoya University
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TAMURA Kazuhiro
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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KOGO Hiroshi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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Kogo H
Department Of Pharmacology Tokyo College Of Pharmacy
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Kogo Hiroshi
東京薬科大学 内分泌分子薬理学
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Kogo Hiroshi
Department Of Electrical Engineering Chiba University
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Kogo H
Deparfment Of Anatomy And Molecular Cell Biology Nagoya University Graduate School Of Medicine
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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TAMURA Hiroshi
Pharmarise Co., Ltd., Nishishinjuku Indensu Kodama Bidg
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HASHIBA Hirotake
Department of Endocrine Pharmacology, Tokyo University of Pharmacy & Life Science
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AIZAWA Sumio
Nakano Ekota Hospital
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Tamura Kazuhiro
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Tamura Kazuhiro
Department Of Endocrine Pharmacology Tokyo University Of Pharmacy And Life Science
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Suzuki Yusuke
Department Of Chemistry Faculty Of Science Toho University
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Hashiba Hirotake
Department Of Endocrine Pharmacology Tokyo University Of Pharmacy & Life Science
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Suzuki Yusuke
Department Of Endocrine Pharmacology Tokyo University Of Pharmacy & Life Science
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Suzuki Yusuke
Department Of Biomolecular Science Faculty Of Engineering Gifu University
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Tamura Hiroshi
Pharmarise Co. Ltd.
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Suzuki Yusuke
Department Of Biological Production Akita Prefectural University
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TAMURA Kazuhiro
Department of Endocrine and Neural Pharmacology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan
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