17β-Estradiol Alters Isoproterenol-Induced Relaxation in Rat Aortic Rings
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概要
- 論文の詳細を見る
Female Wistar rats were treated with 17β-estradiol (E2) (10 μg, s.c.) or with sesame oil for 3 days. The relaxation induced by isoproterenol (10-9-3×10-6 M) in aortae precontracted with norepinephrine was significantly suppressed in aortae from E2-treated rats compared with the relaxation in those from control rats. NG-Nitro-L-arginine, a nitric oxide synthase inhibitor, inhibited isoproterenol-induced relaxation in aortae from both E2-treated and control rats. Metyrapone, a cytochrome P-450 monooxygenase inhibitor, inhibited it in aortae from control rats, but metyrapone enhanced the maximum relaxation in aortae from E2-treated rats. These results suggest that E2 modulates isoproterenol-induced vasodilation through nitric oxide and cytochrome P-450-dependent metabolites.
- 社団法人 日本薬理学会の論文
- 1998-08-01
著者
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Yamaguchi Kiyoshi
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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Honda H
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Honda Hideo
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Honda Hideo
Department Of Ophthalmology Nagoya City University Medical School
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KOGO Hiroshi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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Kogo H
Department Of Pharmacology Tokyo College Of Pharmacy
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Kogo Hiroshi
東京薬科大学 内分泌分子薬理学
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Kogo Hiroshi
Department Of Electrical Engineering Chiba University
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Kogo H
Deparfment Of Anatomy And Molecular Cell Biology Nagoya University Graduate School Of Medicine
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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Yamaguchi Kiyoshi
Department Of Pharmacology Tokyo University Of Pharmacy And Life Science
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Yamaguchi Kiyoshi
Department Of Geriatric Medicine Graduate School Of Medicine University Of Tokyo
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Honda Hideo
東京薬科大学 薬理
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Yamaguchi Kiyoshi
Department Of Electronic Engineering Osaka Institute Of Technology
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