Direct Ovarian Effects of a GnRH Agonist in Hypophysectomized Immature Rats : Inhibition of Theca-Interstitial Luteinizing Hormone Receptor mRNA Expression and Induction of Interstitial Cell Differentiation(Reproductive Biology)
スポンサーリンク
概要
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The effect of a gonadotropin-releasing hormone (GnRH) agonist on luteinizing hormone (LH) receptor mRNA expression was examined histologically in the ovaries of immature hypophysectomized (HPX) rats by in situ hybridization. In the ovaries of HPX rats treated with diethylstilbestrol (DES) and pregnant mare serum gonadotropin (PMSG), LH receptor mRNA was expressed in the granulosa cells of mature follicles as well as the theca-interstitial cells. In DES-primed ovaries of rats treated with both GnRH agonist plus PMSG, many follicles were luteinized without ovulation, and the signal of LH receptor mRNA disappeared completely in the theca-interstitial cells as well as the luteinized cells, but remained in the granulosa cells of unaffected mature follicles. The complete suppression of the theca-interstitial LH receptor expression by GnRH agonist was also observed in HPX rats that received no other treatment. On the other hand, the coadministration of a GnRH antagonist with PMSG resulted in the hyperstimulation of follicular growth, accompanied by very strong expression of LH receptor mRNA in the granulosa cells as well as the thecainterstitial cells. In addition, morphological changes in the ovarian interstitial cells were also induced by the administration of GnRH agonist in HPX rats : loose connective tissue decreased and the interstitial cell mass markedly increased. The increase of the interstitial cells became more prominent when rats were treated with GnRH agonist and testosterone simultaneously. These results suggest that GnRH may be an important factor for modulating the interstitial cell function and differentiation in the rat ovary.
- 社団法人日本動物学会の論文
- 2000-01-20
著者
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Mori Takao
Department Of Cardiology Miki City Hospital
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FUJIMOTO TOYOSHI
Department of Anatomy, Faculty of Medicine, Kyoto University
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KOGO Hiroshi
Department of Pharmacology, Tokyo University of Pharmacy and Life Science
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Kogo Hiroshi
Department Of Anatomy And Cell Biology Gunma University School Of Medicine
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Fujimoto Toyoshi
Department Of Anatomy & Cell Biology Nagoya University Graduate School Of Medicine
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Iizuka-Kogo Akiko
Department of Developmental Biology, National Institute for Basic Biology
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Iizuka‐kogo A
Fujita Health Univ. School Of Medicine Toyoake Jpn
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Iizuka-kogo Akiko
Department Of Anatomy I Fujita Health University School Of Medicine
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Mori Takao
Department Of Biological Sciences Graduate School Of Science University Of Tokyo
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Mori Takao
Department Of Applied Chemistry School Of Science And Engineering Waseda University
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Mori Takao
Department of Biological Sciences Graduate School of Science, University of Tokyo
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Iizuka-Kogo Akiko
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine
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