Vitamin A Insufficiency Accelerates the Decrease in the Number of Sperm Induced by an Environmental Disrupter, Bisphenol A, in Neonatal Mice

概要

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Exposure of neonatal mice to an estrogenic endocrine disrupter, bisphenol A, resulted in a malfunction of the testes when the animals became adults. The effect of bisphenol A was cancelled out by concurrent administration of retinol acetate, a naturally occurring metabolite of vitamin A. In contrast, the effect of endocrine disruption became more severe in mice neonatally exposed to bisphenol A and nursed by mothers fed a vitamin A-deficient diet only a few days before and after parturition. These results clearly show that maternal vitamin A is important for relieving in a baby the effect of endocrine disruption caused by environmental xenoestrogens, and suggest that the changes in the content of vitamin A and similar physiological factors in the habitat may be worth considering in studies on environmental disrupters.
社団法人日本動物学会の論文
2001-08-10