Ultrastructural Changes of Endometrium and Myometrium during Development of Adenomyosis in Mice with Ectopic Pituitary Transplants(Endocrinology)

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Ultrastructural changes occurring in the endometrium and myometrium during development of adenomyosis were examined in SHN mice with ectopic pituitary grafts. In the uteri of mice sacrificed 6 weeks after grafting, adenomyosis was at its early developmental stage, stromal fibroblasts invading into the inner myometrium mainly along the blood vessels. The blood vessels running straight across the inner myometrium were more highly developed as compared with those of the control mice bearing no pituitary grafts. Smooth muscle cells of the inner myometrium in the transplanted mice, except for those in proximity to endometrial stroma and blood vessels, ran parallel to the long axis of the uterine horn, unlike the concentric arrangement around the uterine axis in the controls. Muscle cells around the blood vessels were arranged parallel to the vessels. In addition, muscle cells adjacent to the connective tissue layer between the inner and outer myometrium were markedly loosened in the transplanted mice, associated with widening of intercellular spaces. With advance of development of adenomyosis, the inner and outer muscular bundles of the myometrium were distended and in areas of invasion of a large amount of endometrial tissues muscle cells were degenerating. Disintegration of the inner myometrium was further progressed by 14 weeks after transplantion. Associated with these changes in the myometrium, endometrial stromal cells were proliferated and hypertrophied in the pituitary-grafted mice. The relevance of these findings to the development of adenomyosis is discussed.
社団法人日本動物学会の論文
1985-04-15

Ultrastructural Changes of Endometrium and Myometrium during Development of Adenomyosis in Mice with Ectopic Pituitary Transplants(Endocrinology)

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