Effects of Tumor Necrosis Factor on Pregnancy-dependent Mammary Tumors in GR/A Mice
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概要
- 論文の詳細を見る
This experiment was designed to examine the effects of twice daily injections of tumor necrosis factor (TNF; 5μg/0.1 ml physiological saline) on pregnancy-dependent mammary tumor (PDMT) in GR/A mice which appears during pregnancy, disappears soon after parturition and appears again during the subsequent pregnancies. The significantly positive correlation between the size of PDMT and the period of vehicle treatment observed in the control disappeared by TNF treatment. Furthermore, the linear regression coefficient was apparently higher in the control than in the experimental group. The number of PDMT was also decreased by TNF. Immunohistochemical staining of products of c-jun in PDMT was stimulated and those of c-fos and N-myc were inhibited by TNF. TNF had no effects on reproduction and the weights of anterior pituitary, adrenals and ovaries. All results have demonstrated that TNF inhibits the growth of PDMT corresponding to the period of treatment and its effect may be partly through the modulation of some oncogene expression with little influence on the endocrine parameters.
- 社団法人日本動物学会の論文
- 1993-08-16
著者
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Nagasawa Hiroshi
Experimental Animal Research Laboratory Faculty Of Agriculture Meiji University
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Nagasawa Hiroshi
明治大学
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Goto Yoshihide
Experimental Animal Research Laboratory, Meiji University
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Goto Yoshihide
Experimental Animal Research Laboratory Meiji University
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