Effects of Tumor Necrosis Factor on Pregnancy-dependent Mammary Tumors in GR/A Mice
スポンサーリンク
概要
- 論文の詳細を見る
This experiment was designed to examine the effects of twice daily injections of tumor necrosis factor (TNF; 5μg/0.1 ml physiological saline) on pregnancy-dependent mammary tumor (PDMT) in GR/A mice which appears during pregnancy, disappears soon after parturition and appears again during the subsequent pregnancies. The significantly positive correlation between the size of PDMT and the period of vehicle treatment observed in the control disappeared by TNF treatment. Furthermore, the linear regression coefficient was apparently higher in the control than in the experimental group. The number of PDMT was also decreased by TNF. Immunohistochemical staining of products of c-jun in PDMT was stimulated and those of c-fos and N-myc were inhibited by TNF. TNF had no effects on reproduction and the weights of anterior pituitary, adrenals and ovaries. All results have demonstrated that TNF inhibits the growth of PDMT corresponding to the period of treatment and its effect may be partly through the modulation of some oncogene expression with little influence on the endocrine parameters.
- 社団法人日本動物学会の論文
- 1993-08-16
著者
-
Nagasawa Hiroshi
Experimental Animal Research Laboratory Faculty Of Agriculture Meiji University
-
Nagasawa Hiroshi
明治大学
-
Goto Yoshihide
Experimental Animal Research Laboratory, Meiji University
-
Goto Yoshihide
Experimental Animal Research Laboratory Meiji University
関連論文
- Comparison of Mammary Gland Growth and Some Physiological Parameters in a High Mammary Tumor Strain of SHN Mice and ICR, Most Popular and 'Normal' Mice
- Induction of Male Sexual Behaviors by Administration of Testosterone Using Silastic Tubes in Castrated Male and Female Rats : COMMUNICATION : Behavior Biology
- Ultrastructural Changes of Endometrium and Myometrium during Development of Adenomyosis in Mice with Ectopic Pituitary Transplants(Endocrinology)
- Normal and Neoplastic Growth of Mammary Glands and Circulating Levels of Prolactin and Growth Hormone in Mouse Whey Acidic Protein Promoter/Human Growth Hormone (mWAP/hGH) Transgenic Mice
- MOLECULAR ANALYSIS OF GALAXIN, A SOLUBLE SKELETAL MATRIX PROTEIN IN THE SCLERACTINIAN CORAL GALAXEA FASCICULARIS(Biochemistry)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Molecular analysis of a protein in the skeletal organic matrix of the hermatypic coral, Galaxea fascicularis(Biochemistry)(Proceeding of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- ANALYSIS OF SKELETAL PROTEINS IN THE HERMATYPIC CORAL Galaxea fascicularis(Biochemistry)Proceedings of the Seventy-First Annual Meeting of the Zoological Society of Japan
- CDNA CLONING OF AN ANDROGENIC GLAND HORMONE FROM TWO SPECIES OF THE TERRESTRIAL ISOPOD, Porcellio scaber AND P. dilatatus(Endocrinology)(Proceeding of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Transforming Growth Factor-α mRNA and Epidermal Growth Factor Receptor mRNA Expression in Normal and Neoplastic Mammary Glands of Four Strains of Mice with Different Mammary Tumor Potentials
- The mRNA Expression of Neurocan, a Brain-Specific Chondroitin Sulfate Proteoglycan, in Neoplastic Mammary Glands in Mice
- Mouse TGF_α Gene Expression in Normal and Neoplastic Mammary Glands and Uteri of Four Strains of Mice with Different Potentials for Mammary Gland Growth and Uterine Adenomyosis
- Different Gene Expression of Mouse Transforming Growth Factor α between Pregnant Mammary Glands and Mammary Tumors in C3H/He Mice
- Effects of Ovariectomy and Prolactin on Mammary Gland Expressions of Transforming Growth Factor α and Epidermal Growth Factor Receptor mRNAs in Mice
- STRUCTURE AND ACTIVITY OF ANDROGENIC GLAND HORMONE IN ARMADILLIDIUM VULGARE(Endocrinology)(Proceedings of the Seventieth Annual Meeting of the Zoological Society of Japan)
- HISTOCHEMICAL ANALYSIS BY LECTIN IN COMPARISON WITH IMMUNOHISTOCHEMICAL PROLACTIN STAINING OF PRENEOPLASTIC AND NEOPLASTIC MAMMARY GLANDS IN FOUR STRAINS OF MICE
- Hematological and Serum Biochemical Values in Pregnant and Postpartum Females of the Squirrel Monkey (Saimiri sciureus)
- Two Inbred Strains of Mice with High and Low Mammary Tumor Potentials Established from the Same Basal Stock of Swiss Albino (SHN and SLN): History of Mammary Tumorigenesis and Reproduction after the 30th Generation of Full-sib Mating
- Effect of Ovariectomy on Mammary Gland Expression of TGFα and EGFR mRNAs and its Relation to Mammary Gland Involution in Mice
- ANALYSES OF MASCULINIZING PROCESS IN THE FEMALES OF ARMADILLIDIUM VULGARE AFTER IMPLANTATION OF THE ANDROGENIC GLANDS FROM MATURE MALES(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- IMMUNOHISTOCHEMICAL LOCALIZATION AND SPECIES-SPECIFICITY OF ANDROGENIC GLAND HORMONE IN ONISCIDEA(Endocrinology)Proceedings of the Seventy-First Annual Meeting of the Zoological Society of Japan
- Change of Urinary Component Level during Pregnancy and Lactation in Mice
- Effects of Coffee Cherry on Lactation in Mice : Improvement of Nesting Behavior
- Inhibition by Motherwort (Leonurus sibiricus L.) of Precancerous Mammary Hyperplastic Alveolar Nodules in Mice
- INDUCTION MECHANISMS BY PROLACTIN OF MAMMARY TUMOR, UTERINE ADENOMYOSIS AND PANCREATIC TUMOR IN MICE : Endocrinology
- Effects of Tumor Necrosis Factor on Pregnancy-dependent Mammary Tumors in GR/A Mice