Mouse TGF_α Gene Expression in Normal and Neoplastic Mammary Glands and Uteri of Four Strains of Mice with Different Potentials for Mammary Gland Growth and Uterine Adenomyosis

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概要

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• The expression of TGF_α mRNA and the protein localization in the mammary glands were determined by RT-PCR and immunohistochemical staining methods, respectively, in four strains of mice (SHN, SLN, GR/A and C3H/He), which had different potentials for normal and neoplastic mammary gland growth and uterine adenomyosis. TGF_α gene expression was detected in some virgin and pregnant mammary glands of 4 strains and in all lactating glands of SHN, GR/A and C3H/He mice, but not in SLN. The results of immunohistochemical staining of pregnant and lactating mammary glands corresponded well with those of RT-PCR in all strains except SLN. These suggest that there is a strain-related difference in the pattern of TGF_α gene expression during the reproductive states. Meanwhile, little difference was observed among strains in TGF_α gene expression after retirement ; in retired mammary glands, some samples expressed TGF_α mRNA and all samples were stained positively in 4 strains. All samples of mammary tumors showed both TGF_α mRNA expression and immunohistochemically positive staining. Neither RT-PCR nor immunohistochemical staining showed positive results in uterus in all strains except one sample in GR/A. All findings in this study indicate that TGF_α expression itself is not always directly related to the potentials for normal and neoplastic mammary gland growth and uterine adenomyosis in mice. In all strains, several different sizes of PCR products were observed besides the predicted size of product in mammary tumors and lactating and/or retired mammary glands. These suggest that mammary glands may possess sooner or later neoplastic characteristics that include an over expression of TGF_α during and after reproductive states.

• 社団法人日本動物学会の論文
• 1994-12-15

著者

• YAMAMOTO Kazutoshi

  Department of Biology, School of Education, Waseda University

• Yamamoto Kazutoshi

  Department Of Biology School Of Education Waseda University

• Yokoyama Hitoshi

  Tohoku Univ. Sendai

• HARIGAYA Toshio

  Laboratory of Functional Anatomy, Department of Life Sciences, Faculty of Agriculture, Meiji Univers

• Nagasawa Hiroshi

  Experimental Animal Research Laboratory, Meiji University, Tama-ku, Kawasaki 214-71, Japan

• Harigaya Toshio

  Laboratory Of Functional Anatomy Department Of Life Sciences Faculty Of Agriculture Meiji University

• Harigaya Toshio

  Faculty Of Agriculture Meiji University

• Hasegawa T

  Japan Racing Horse Assoc. Utsunomiya‐shi Jpn

• Nagasawa Hiroshi

  Experimental Animal Research Laboratory Faculty Of Agriculture Meiji University

• Hosoyama Tohru

  Department Of Veterinary Physiology Graduate School Of Agricultural And Life Sciences The University

• Tsunoda S

  Meiji Univ. Kawasaki Jpn

• Tsunoda Satoshi

  Experimental Animal Research Laboratory Meiji University

• Yokoyama Hidenori

  Experimental Animal Research Laboratory, Meiji University

• Harigaya T

  Department Of Anatomy Faculty Of Medicine Kyoto University

• Nagasawa H

  Experimental Animal Research Laboratory Meiji University

• Yokoyama Hidenori

  Department Of Developmental Biology And Neurosciences Graduate School Of Life Sciences Tohoku Univer

• Nagasawa Hiroshi

  Dept. Of Applied Biol. Chem. Grad. Sch. Ofagri. And Life Sci. Univ. Of Tokyo

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