Prolactin Binding Sites in Normal Uterus and the Uterus with Adenomyosis in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Radioreceptor assay for mouse prolactin (mPRL) was developed in the mouse uterus. The specific binding of [^<125>I]-mPRL to the uterine preparations was demonstrated and the binding was found to have a similar affinity to that in the liver preparations. The specific PRL-binding to the uterine preparations tended to increase after estrogen treatment, while the differences among the three groups, diestrous intact, ovariectomized, and ovariectomized and estrogen-treated mice, were statistically not significant. Immunohistochemical staining of PRL revealed that PRL immunoreactivity was preferentially localized in the myometrial cells. Pituitary grafting into the uterus induced a high incidence of adenomyosis associated with the increase in plasma PRL levels. Furthermore, the PRL-binding activity in the uterus with adenomyosis was significantly higher than that in normal uterus. These results indicate that the elevation of PRL binding in the uterus, hyperprolactinemia, and the development of adenomyosis are interrelated.
- 社団法人日本動物学会の論文
- 1993-04-15
著者
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Singtripop Tippawan
Zoological Institute Faculty Of Science University Of Tokyo
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Singtripop Tippawan
東京大学 理
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Kawashima Seiichiro
Research Laboratory, Zenyaku Kogyo Co.,Ltd.
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Mori Takao
Zoological Institute, Graduate School of Science, University of Tokyo
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Kawashima Seiichiro
Zoological Institute, Graduate School of Science, University of Tokyo
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HARIGAYA Toshio
Laboratory of Functional Anatomy, Department of Life Sciences, Faculty of Agriculture, Meiji Univers
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Shiraishi Koichi
Zoological Institute, School of Science, University of Tokyo
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Park Kyun
Zoological Institute, School of Science, University of Tokyo
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Harigaya Toshio
Laboratory Of Functional Anatomy Department Of Life Sciences Faculty Of Agriculture Meiji University
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Harigaya Toshio
Laboratory Of Functional Anatomy Faculty Of Agriculture Meiji University
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Kawashima Seiichiro
Department Of Biosciences Research Laboratory Zenyaku Kogyo Co. Ltd.
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Park Kyun
Zoological Institute Faculty Of Science University Of Tokyo
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Kawashima S
Research Laboratory Zenyaku Kogyo Co. Ltd.
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Kawashima Seiichiro
Zoological Institute Faculty Of Science Hiroshima University
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Shiraishi K
Univ. Tokyo Tokyo Jpn
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Mori Takao
Zoological Institute Faculty Of Science Graduate School Of Agricultural Sciences University Of Tokyo
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Shiraishi Koichi
Zoological Institute, Faculty of Science, University of Tokyo
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Harigaya Toshio
Laboratory of Functional Anatomy, Faculty of Agriculture, Meiji University
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