Effects of Chlorpromazine and Estradiol Benzoate on Prolactin Secretion in Gonadectomized Male and Female Rats
スポンサーリンク
概要
- 論文の詳細を見る
The effects of chlorpromazine (CPZ) and estradiol benzoate (EB) on serum prolactin (PRL) levels were studied in gonadectomized male and female rats. In both sexes CPZ (25mg/kg body weight) produced an elevation of PRL when measured 2hr after the injection, but the elevated levels were higher in ovariectomized rats than in orchidectomized rats. These results reconfirm a sexual difference in the regulatory mechanism of PRL secretion in response to the dopamine receptor blocker. Pretreatment with 5μg EB 48hr before CPZ injection abolished this sexual difference in serum PRL concentration.
- 社団法人 日本内分泌学会の論文
著者
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Wakabayashi Katsumi
Institute For Molecular And Cellular Regulation Gunma University
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TAKAHASHI SUMIO
Zoological Institute, Faculty of Science, Hiroshima University
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Kawashima Seiichiro
Zoological Institute Faculty Of Science Hiroshima University
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Takahashi Sumio
Zoological Institute Faculty Of Science Hiroshima University
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TAKAHASHI SUMIO
Zoological Institute, Faculty of Science, University of Tokyo
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