Spatio-Temporal Pattern of DNA Synthesis Detected by Bromodeoxyuridine Labeling in the Mouse Endometrial Stroma during Decidualization

概要

論文の詳細を見る
In order to examine the patterns of proliferation and differentiation of endometrial stromal cells before and during decidualization in pseudopregnant mice, the rate of DNA synthesis was immunocytochemically determined by means of bromodeoxyuridine (BrdU) labeling. On day 4 of pseudopregnancy induced by mating with vasectomized male, both uterine horns were traumatized to induce deciduoma. On day 5 of pseudopregnancy (one day after traumatization), BrdU-labeling index was markedly increased, and the labeled cells were found in almost all parts of endometrial stroma. From day 6 to day 8 of pseudopregnancy (2-4 days after traumatization), the labeling index remained high in the stromal cells of all parts except for the periluminal region. In the endometrial stromal cells in the peripheral region of myometrium , however, the labeling index was maximum on day 8 and decreased remarkably on day 9. In the stromal cells in the periluminal region where deciduomal cells developed, the labeling index was high on day 5 and low on day 6, no labeled cells being found on day 8. There results clearly show that each region of uterine endometrial stroma has a different responsiveness to traumatization, and each region plays a different role in the formation of deciduoma.
社団法人日本動物学会の論文
1994-04-15