Age-Related Changes and Sex Difference in the Ultrastructure of Renal Glomerulus in Wistar/Tw Rats : Morphology
スポンサーリンク
概要
- 論文の詳細を見る
Changes in the renal glomerulus were electron microscopically examined in male and female rats of the Wistar/Tw strain at 1, 3, 6, 12 and 18 months of age. Initial lesions as focal thickening of the glomerular capillary basement membrane (GBM) and the fusion of glomerular epithelial cell foot processes (EpF) were encountered at 3 months in male and at 6 months in female rats. Twelve-month-old female rats showed focal thickening of the GBM with fusion of the EpF and the formation of vacuoles. At 18 months focal thickening of the GBM became segmental with fusion of the EpF and frequent occurrence of fusion of the mesangial matrix to the GBM. At 12 and 18 months, there were striking sex differences in the severity of the renal lesions. Only 12- and 18-month-old male rats showed extensive thickening of the GBM with nodular folds intermingled with massive mesangial matrix, extensive fusion, denudation of the EpF and degeneration of the epithelial cells.
- 社団法人日本動物学会の論文
- 1989-08-15
著者
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Kawashima Seiichiro
Zoological Institute, Graduate School of Science, University of Tokyo
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Yee W
Zoological Institute Faculty Of Science Hiroshima University
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Takahashi S
Zoological Institute Faculty Of Science Hiroshima University
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YEE WIN
Zoological Institute, Faculty of Science, Hiroshima University
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TAKAHASHI SUMIO
Zoological Institute, Faculty of Science, Hiroshima University
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Yee Win
Zoological Institute Faculty Of Science Hiroshima University
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Kawashima Seiichiro
Zoological Institute Faculty Of Science Hiroshima University
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Takahashi Sumio
Zoological Institute Faculty Of Science Hiroshima University
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