Effects of Estrogen Treatment on Persistent Hyperplastic Lesions of the Vagina in Neonatally Estrogenized Mice
スポンサーリンク
概要
- 論文の詳細を見る
Female mice of B6AF1 hybrids (C57BL/6N×A/HeN) were treated neonatally with 5 daily injections of 20μg estradio1-17β or sesame oil from the day of birth. About half of them were ovariectomized at 40 days of age, and the other were given an implantation of an estradiol-17β pellet under the dorsal skin at 80 days of age. The pellet was removed 30 days later. Vaginal smear records showed persistent vaginal cornification in a number of neonatally estrogenized mice regardless of ovariectomy. When killed at 16-21 months or at 24-32 months of age, hyperplastic lesions ranging histologically from those resembling squamous cell carcinomas to adenosislike structures were observed in neonatally estrogenized mice. The development of lesions was more pronounced in mice killed at 24-32 months of age than at 16-21 months. Secondary estrogen treatment when adults did not appreciably affect the promotion of lesions. It is therefore evident that neonatal exposure to high doses of estrogen was important primarily in connection with the neoplastic changes in the cervicovaginal tract.
- 社団法人 日本内分泌学会の論文
著者
-
Mori Takao
Zoological Institute, Graduate School of Science, University of Tokyo
-
Arai Yasumasa
Department Of Anatomy Juntendo University School Of Medicine
-
Kawashima Seiichiro
Zoological Institute Faculty Of Science Hiroshima University
-
NISHIZUKA YASUAKI
Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute
-
KIMURA TAKEJI
Biology Laboratory, College of General Education, University of Tokyo
-
Mori Takao
Zoological Institute Faculty Of Science Graduate School Of Agricultural Sciences University Of Tokyo
-
Arai Yasumasa
Department Of Anatomy Jaunted University Scool Of Medicine
-
MORI TAKAO
Zoological Institute, Faculty of Science, University of Tokyo
関連論文
- The Difference in Autofluorescence Features of Lipofuscin between Brain and Adrenal
- Occurrence of a Novel 350-kDa Serine Proteinase in the Fluid of Porcine Ovarian Follicles and Its Increase during Their Maturation(Reproductive Biology)
- Induction of Male Sexual Behaviors by Administration of Testosterone Using Silastic Tubes in Castrated Male and Female Rats : COMMUNICATION : Behavior Biology
- Developmental Changes of Testicular Gonadotropin Receptors and Serum Gonadotropin Levels in Two Strains of Mice
- Prolactin Binding Sites in Normal Uterus and the Uterus with Adenomyosis in Mice
- Ultrastructural Changes of Endometrium and Myometrium during Development of Adenomyosis in Mice with Ectopic Pituitary Transplants(Endocrinology)
- Normal and Neoplastic Growth of Mammary Glands and Circulating Levels of Prolactin and Growth Hormone in Mouse Whey Acidic Protein Promoter/Human Growth Hormone (mWAP/hGH) Transgenic Mice
- Age-Related Changes and Sex Difference in the Ultrastructure of Renal Glomerulus in Wistar/Tw Rats : Morphology
- Spatio-Temporal Pattern of DNA Synthesis Detected by Bromodeoxyuridine Labeling in the Mouse Endometrial Stroma during Decidualization
- HISTOCHEMICAL ANALYSIS BY LECTIN IN COMPARISON WITH IMMUNOHISTOCHEMICAL PROLACTIN STAINING OF PRENEOPLASTIC AND NEOPLASTIC MAMMARY GLANDS IN FOUR STRAINS OF MICE
- Binding Properties and Photoperiodic Influence of Follicle-Stimulating Hormone Receptors in the Subtropical Wild Quail(Endocrinology)
- Effects of Unilateral and Bilateral Orchidectomy on Laterality of Neurons of the Preoptic Area and Plasma Levels of Gonadotropins and Testosterone in Male Mice(Endocrinology)
- Straying phenomenon of migrating LHRH neurons and highly polysialylated NCAM in the chick embryo
- Cell surface-associated extracellular distributi9on of a neural proteoglycan, 6B4 proteoglycan/phosphacan, in the olfactory epithelium, olfactory nerve, and cells migrating along the olfactory nerve in chick embryos
- Isolation of Rat GnRH Receptor cDNA having Different 5'-Noncoding Sequence
- Effects of Sex Steroids on Dopamine Neurons in Cultured Hypothalamus and Preoptic Area Cells Derived from Neonatal Rats
- Influence of Continued Injections of Sex Steroids on the Estrous Cycle in theAdult Rat
- OBITUARY
- In Situ Hybridization Study of Gonadotropin-Releasing Hormone (GnRH) Receptor mRNA in Female Rat Pituitary Gland during Estrous Cycle and after Ovariectomy
- Attempts to Improve Survival of Neurons Derived from Neonatal Rat Hypothalamus-Preoptic Area in Serum-free Media(Cell and Molecular Biology)
- Regulation of Gonadotropin Receptors and Its Physiological Signiticance in Higher Vertebrates
- ONTOGENY OF GnRH NEURONS IN EARLY HUMAN EMBRYOS AND EXPRESSION OF THE EMBRYONIC NCAM(NCAM-H)
- Histometric Study of the Pituitary in Mice Treated Neonatally with Steroids and the Relationship between Prolactin Cells and Mammary Tumorigenesis
- Effects of Chlorpromazine and Estradiol Benzoate on Prolactin Secretion in Gonadectomized Male and Female Rats
- Stimulation of Neuronal Process Growth by Estradiol-17β in Dissociated Cells from Fetal Rat Hypothalamus-Preoptic Area(Endocrinology)
- Micro-radioreceptor Assay of Testicular FSH Receptors and Its Application to Fetal Rat Testes(COMMUNICATION)(Endocrinology)
- Effects of Prenatal Treatment with Estrogen on Mitotic Activity of Vaginal Anlage Cells in Mice
- Effects of Estrogen Treatment on Persistent Hyperplastic Lesions of the Vagina in Neonatally Estrogenized Mice
- SPONTANEOUS ACTIVITY OF NEONATALLY ESTROGENIZED FEMALE RATS
- Dopamine and Background Adaptation in Bullfrog Tadpoles (Rana catesbeiana): A Pharmacologicaland Histofluorescence Study
- Effect of Naloxone on Background Adaptation in Bullfrog Tadpoles (Rana catesbeiana)
- Supportive Role of Cellular Bridge of Neurons Expressing a Highly Polysialylated Form of NCAM (NCAM-H) at the Initial Stage of Migration of LHRH Neurons
- Responsiveness to Estrogen of Pituitary Glands and Prolactin Cells in Gonadectomized Male and Female Rats
- Immunohistochemical Analysis of Androgen Receptor in the Abdominal Glands of the Cloaca of Male Red-Bellied Newts, Cynops pyrrhogaster
- Glycosaminoglycans in the olfactory epithelium and nerve of chick embryos: an immunocytochemical study
- Heterotypical Sexual Behavior in Male Rats : Individual Difference in Lordosis Response
- Forebrain Lordosis Inhibiting System and Serotonin Neuron in Female Rats : Effect ofP-chloroamphetamine
- Female Lordosis Pattern in the Male Rat Induced by Estrogen and Progesterone: Effect of Interruption of the Dorsal Inputs to the Preoptic Area and Hypothalamus
- Effects of Hypothalamic Deafferentation on Hormonal Facilitation of Lordosis in Ovariectomized Rats
- MIGRATION OF SOMATOSTATIN IMMUNOREACTIVE CELLS FROM THE OLFACTORY PLACODE TO THE FOREBRAIN IN THE CHICK EMBRYO
- Irreversible Lesions in Female Reproductive Tracts of Mice after Prenatal Exposure to Testosterone Propionate
- Androgenic Regulation of Neuron Number in the Developing Hypogastric Ganglion of Mice(COMMUNICATION)(Endocrinology)
- Alkaline Phosphatase Activity in Estrogen-Induced Metaplastic Epithelium of Mouse Coagulating Gland:Effect of Androgen after the Cessation of Estrogen Treatment
- Morphological Changes of the Cumulus Cells of the Mouse Ovary after the Gonadotropin Surge
- Fetal and Postnatal Development of Arginine Vasopressin-Immunoreactive Neurons in the Mouse : Endocrinology
- Some Effects of Neonatal Administration of Androgen or Estrogen in Female Rats
- Aging of Endocrine Systems in Mammals : THE ZOOLOGICAL SOCIETY PRIZE : Abstracts of papers read by the Zoological Society Prize winners
- Basophils and Erythrosinophils in the Anterior Hypophysis of Steroid-Sterilized Female Rats
- Paper Based of Invited Discussion (2) : Morphology and Function of Prolactin Cells in Old Female Rats
- Androgen Secretion by Ovarian Grafts in Orchidectoized Rats
- The Effect of Dehydration on Neurosecretion in the Hypothalamo-Hypophysial System in Normal,Persistent-Estrous and-Diestrous Rats
- Stimulation of Nuclear Volume Enlargement and Neuronal Process Growth by Estrogen in the Hypothalamic and Limbic Nuclei of the Rat : Endocrinology
- Secretion of Gonadotropins by the Anterior Hypophysis in Orchidectomized Rats
- Inhibitory Action of Reserpine on the Development of the Male Pattern of Secretion of Gonadotropins in the Rat
- The Effects of Estradiol-17β on the Neuritic Growth of Neonatal Mouse Hypothalamus and Preoptic Area in Primary Culture
- Immunofluorescence Analysis of Estrogen Receptor in Adult and Neonatal Mouse Vagina
- Changes in Alkaline Phosphatase Activity and Mitotic Rate in Vaginal Epithelium Following Estrogen Injections in Neonatally Estrogenized Mice
- Effects of Pituitary implantation performed on the day of birth in female rats(短報)
- Changes in Reproductive Organs and Some Other Glands in Old C3H/MS Mice Treated Neonatally with Low Doses of Estrogen
- Effects of Ergocornine on Reserpine-induced Lactogenic Response of Male Rat Mammary Glans
- Initiation of Milk Secretion in the Male Rat by Single Injections of Reserpine
- Effect of Electrochemical Stimulation of the Amygdala on Induction of Ovulation in Different Types of Persistent Estrous Rats and Castrated Male Rats with an Ovarian Transplant
- LONG-LASTING EFFECTS OF PREPUBERTAL ADMINISTRATION OF ANDROGEN ON MALE HYPOTHALAMIC-PITUITARYGONADAL SYSTEM
- Effect of Electrochemical Stimulation of the Preoptic Area on Induction of Ovulation in Estrogenized Rats
- Effect of 5α-Dihydrotestosterone on Differentiation of Masculine Pattern of the Brain in the Rat
- Sexual Differentiation of Neural Circuits : Implications for Sexually Dimorphic Neuroendocrine and Behavioral Brain Functions(THE ZOOLOGICAL SOCIETY PRIZE)(Proceedings of the Fifty-Fifth Annual Meeting of the Zoological Society of Japan)
- Advancement of Masculine Differentiation of the Brain by Synthetic LH-Releasing Hormone (LH-RH) in the Male Rat
- Effect of Hypothalamic Deafferentation of Reserpine-Induced Lactogenesis in Female Rats
- Neural and Hormonal Control of Lordosis Behavior in the Rat
- Sex Difference in Volume of the Ventromedial Nucleus of the Hypothalamus in the Rat
- Ultrastructural Characteristics of the Vaginal Epithelium of Neonatally Estrogenized Mice in Response to Subsequent Estrogen Treatment
- INDUCTION MECHANISMS BY PROLACTIN OF MAMMARY TUMOR, UTERINE ADENOMYOSIS AND PANCREATIC TUMOR IN MICE : Endocrinology
- Effects of Neonatal Injections of Estrogen in Combination with Vitamin A on the Vaginal Epithelium of Adult Mice
- Reproductive Activity with Refrence to Life Span in the Pond Snail, Bakerlymnaea viridis
- Effect of LH or HCG on Differentiation of Masculine Pattern of Gonadotropin Regulation in the Male Rat
- Long-term effects of perinatal exposure to 5.ALPHA.-dihydrotestosterone on normal and neoplastic mammary development in mice.
- Possible linkage between developmental disorder of the gubernaculum testis and cryptorchidism in male mice exposed prenatally to diethylstilbestrol.
- The binding of rat luteinizing hormone (rLH) to slices of luteinized ovaries and intrasplenic ovarian grafts.
- Lower Incidence of Nodular Hyperplasia of the Adrenal Cortex after Ovariectomy in Neonatally Estrogenized Mice than in the Controls
- 124. Polydipsia and Polyuria in Aged Male Rats of the Wistar/Tw Strain
- Effect of prolactin on post-castration changes in ultrastructure of the ventral prostates in male rats.
- The binding of rat luteinizing hormone (.GAMMA.LH), rat follicle stimulating hormone (.GAMMA.FSH) and rat prolactin (.GAMMA.PRL) to dissociated cells of luteinized ovaries and intrasplenic ovarian grafts.