Irreversible Lesions in Female Reproductive Tracts of Mice after Prenatal Exposure to Testosterone Propionate
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概要
- 論文の詳細を見る
Female mice of the C3H/HeMs strain were given a single subcutaneous injection of various doses of testosterone propionate (TP) on Day 15 or 17 of fetal life or on the day of birth. Irreversible ovary-independent vaginal cornification and uterine stratification with or without squamous metaplasia were most frequently observed in mice given TP injections on Day 17 of fetal age. Vaginae of many mice given prenatal injection of higher doses of TP failed to form the orifice, whereas the orifice was always normally formed in neonatally injected mice. In contrast, it seemed probable that hypothalamic function was affected in less extent by prenatal treatment than by postnatal treatment. Of interest was that some mice with the vaginal lesion had normal reproductive capacity when they did not show uterine stratification.
- 社団法人 日本内分泌学会の論文
著者
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TAGUCHI Osamu
Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute
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NISHIZUKA YASUAKI
Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute
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Takasugi Noboru
Department Of Biology Yokohama City University
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Taguchi Osamu
Laboratory Of Experimental Pathology Aichi Cancer Center Research Institute
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Nishizawa Yasuaki
Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute
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- OBITUARY
- Lower Incidence of Nodular Hyperplasia of the Adrenal Cortex after Ovariectomy in Neonatally Estrogenized Mice than in the Controls