Critical Period of Induction by Tamoxifen of Genital Organ Abnormalities in Male Mice : COMMUNICATION : Developmental Biology
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概要
- 論文の詳細を見る
C57BL/Tw male mice given 5 daily injections of 100 μg tamoxifen (Tx) starting on the day of birth (0 day) were examined at 5, 10, 15, 20 and 30 days of age. Body and organ weights and diameter of seminiferous tubules in Tx mice were significantly smaller than those of the age-matched controls. Spermatogenesis was found in 30-day-old control mice, but was completely suppressed in Tx mice at the same age. In addition, 60-day-old male mice given neonatal injections of 100μg clomiphene (Clm) or nafoxidine (Naf), and those given injections of 100 μg Tx beginning at different early postnatal ages were also examined. Tx caused more damage to testis than did Clm and Naf. Mean spermatogenic index and diameters of seminiferous tubules in mice given Tx beginning at 0 day were significantly smaller than those in mice given Tx starting at 5 days. These findings suggest that the critical period of producing the deleterious effects of Tx on the genital organs is present within 3 days after birth.
- 社団法人日本動物学会の論文
- 1990-06-15
著者
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Iguchi Taisen
Okazaki Institute For Integrative Bioscience National Institute For Basic Biology National Institute
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Iguchi Taisen
Department Of Bio-enviromental Research Center For Integrative Bioscience National Institute For Bas
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Iguchi T
Yokohama City Univ. Yokohama Jpn
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Takasugi N
Department Of Biology Yokohama City University
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Takasugi Noboru
Department Of Biology Yokohama City University
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IRISAWA SATOKO
Laboratory Biology, Tokyo Kasei University
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Irisawa Satoko
Laboratory Biology Tokyo Kasei University
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IGUCHI Taisen
Department of Basic Biology, Faculty of Life Science, The Graduate School for Advanced Studies (SOKENDAI), and Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5–1 Higashiyama, My
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TAKASUGI Noboru
Department of Biology
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- Inhibitory Effect of Androgen on Induction of Permanent Changes in the Testis by Neonatal Injections of Estrogen in Mice
- Critical Period of Induction by Tamoxifen of Genital Organ Abnormalities in Male Mice : COMMUNICATION : Developmental Biology
- Testicular Damages in Neonatally Estrogenized Adult Mice
- Effects of Continuous Intravenous Infusion of Diethylstilbestrol into Pregnant Mice on Fetus: Testicular Morphology at Fetal and Postnatal Period
- Effects of Gonadotropins on the Occurrence of Permanent Changes in the Testis of Mice Given Neonatal Estrogen Injections
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- OBITUARY
- P21 and Notch Signalings in the Persistently Altered Vagina Induced by Neonatal Diethylstilbestrol Exposure in Mice
- Occurrence of polyovular follicles in ovaries of mice treated neonatally with diethylstilbestrol.
- Changes in male genital organs of mice exposed neonatally to tamoxifen.
- Restoration of normal responsiveness of vaginal and uterine epithelia to estrogen in neonatally estrogenized, A-vitaminized adult mice.
- Regression of mammary and adrenocortical tumors transplanted into iodotyrosine-pretreated mice.