P21 and Notch Signalings in the Persistently Altered Vagina Induced by Neonatal Diethylstilbestrol Exposure in Mice
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概要
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Female reproductive organs show organ-specific morphological changes during estrous cycles. Perinatal exposure to natural and synthetic estrogens including diethylstilbestrol (DES) or estrogenic chemicals induces estrogen-independent persistent proliferation of vaginal epithelium in mice. To understand the underlying mechanism of the estrogen-independent persistent vaginal changes induced by perinatal DES exposure, we examined global gene expressions in the vaginae of ovariectomized adult mice exposed neonatally to DES using microarray. Cell cycle-related genes, p21, cyclin-dependent kinase inhibitor, showed up-regulation in the vagina and p21 protein was localized in the basal layer of the vaginal epithelium in mice exposed neonatally to DES and estrogen receptor α agonist, propyl pyrazole triol (PPT). The expression of Notch receptors and Notch ligands were unchanged, however, hairy-related basic helix-loop-helix (bHLH) transcription factor genes, Hes1, Hey1 and Heyl mRNA were persistently down-regulated in the vagina showing estrogen-independent epithelial cell proliferation in mice exposed neonatally to DES and PPT.
著者
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Katsu Yoshinao
Department Of Bioenvironmental Reserch Center For Integrative Bioscience Okazaki National Research I
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Ohta Yasuhiko
Department O Fbiology School Of General Education Tottori University
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Takeuchi Takashi
Department Of Chemical Engineering Science Yokohama National University
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Nakamura Takeshi
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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Miyagawa Shinichi
Department Of Hepatobiliary Pancreatic Surgery Shinshu University School Of Medicine
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IGUCHI Taisen
Department of Basic Biology, Faculty of Life Science, The Graduate School for Advanced Studies (SOKENDAI), and Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5–1 Higashiyama, My
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MIZUTANI Takeshi
Department of Basic Biology, Faculty of Life Science, The Graduate School for Advanced Studies (SOKENDAI), and Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5–1 Higashiyama, My
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SATO Tomomi
International Graduate School of Arts and Sciences, Yokohama City University, Yokohama 236–0027, Japan
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MIYAGAWA Shinichi
Department of Basic Biology, Faculty of Life Science, The Graduate School for Advanced Studies (SOKENDAI), and Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5–1 Higashiyama, My
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KATSU Yoshinao
Department of Basic Biology, Faculty of Life Science, The Graduate School for Advanced Studies (SOKENDAI), and Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5–1 Higashiyama, My
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