Persorption of Bovine Lactoferrin from the Intestinal Lumen into the Systemic Circulation via the Portal Vein and the Mesenteric Lymphatics in Growing Pigs
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概要
- 論文の詳細を見る
The absorption and the transportation of intestinally administrated bovine lactoferrin (LF) were immunohistochemically and physiochemically investigated in the small intestine of growing pigs. At the apical halves of the small intestinal villi, bovine LF was absorbed by transcytosis as small vesicles through villous columnar epithelial cells. The presence of bovine LF-positive membranes of transcytotic vesicles suggests that the absorption was mediated by LF-binding factors on the epithelial cell membranes. Almost all of the absorbed bovine LF was demonstrated to be transported via the lymphatics and the portal vein into the systemic circulation. The LF-concentration in systemic circulation was significantly higher at 1 hr following intestinal administration of bovine LF. Bovine LF-positive lymphocytes also were transferred into the systemic circulation from intestine via the lymphatics and the portal vein.
- 公益社団法人 日本獣医学会の論文
著者
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ANDO Kunio
Nuclear Receptor Institute, KSP
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Harada Etsumori
Department Of Physiology Faculty Of Veterinary Medicine Hokkaido University
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Yokoyama Toshifumi
Department Of Anatomy And Neurobiology Faculty Of Medicine Kagawa University
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Yoshizawa Yumiko
Department Of Chemistry Faculty Of Science Hokkaido University
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Takeuchi Takashi
Department Of Chemical Engineering Science Yokohama National University
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Kitagawa Hiroshi
Department Of Adaptive Machine Systems Graduate School Of Engineering Osaka University
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ANDO Kunio
Nuclear Receptor Ligand Co. Ltd.
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TALUKDER Mohammad
Department of Veterinary Physiology, Faculty of Agriculture, Tottori University
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SHIMIZU Hirohiko
Nuclear Receptor Ligand Co. Ltd.
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YOKOYAMA Toshifumi
Department of Life Science, Graduate School of Science and Technology, Kobe University
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