Persorption of Luminal Antigenic Molecule and Its Specific Antibody via Apoptotic Epithelial Cells of Intestinal Villi and Peyers Patches into Peripheral Blood in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The possibility of persorption of bovine serum albumin (BSA) molecules from mucous epithelial cells and its mechanism were investigated in rats orally pre-immunized by BSA for 14 consecutive days. In the small and large intestines, both the BSA antigen (BSA-Ag) and its specific antibody (SpAb) were absorbed by the epithelial cells at the late apoptotic stage (ApoEp), and were subsequently transcytosed by membranes of the small vesicles. The basal cytoplasms containing highly-concentrated BSA-Ag and SpAb were occasionally fragmented into small cytoplasmic droplets that were secreted into the lamina propria. In Peyers patches, both BSA-Ag and SpAb were more actively absorbed and transcytosed toward the dome area by the ApoEp of the dome apex than by the M cells. BSA-Ag and SpAb were finally persorbed into the portal blood and lymph, but were never secreted into the bile. They were also engulfed by macrophage-like cells in the villous lamina propria, mesenteric lymph node and spleen, and by hepatocytes in the liver. These findings suggest that sensitized soluble luminal antigens are taken up by ApoEp in the small intestine and are finally persorbed into the peripheral blood. The uptake of luminal antigen might be mediated by its luminal SpAb.
著者
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Inamoto Tetsurou
Department Of Bioresource And Agrobiosciences Graduate School Of Science And Technology Kobe Univers
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Yokoyama Toshifumi
Department Of Anatomy And Neurobiology Faculty Of Medicine Kagawa University
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Warita Katsuhiko
Department Of Anatomy And Neurobiology Faculty Of Medicine Kagawa University
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Kitagawa Hiroshi
Department Of Adaptive Machine Systems Graduate School Of Engineering Osaka University
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Hoshi Nobuhiko
Department Of Animal Science Graduate School Of Agricultural Science Kobe University
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QI Wang-Mei
Department of Based Veterinary Medicine, College of Veterinary Medicine, Inner Mongolia Agricultural University
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YUJI Midori
Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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Inamoto Tetsurou
Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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Onishi Sachiko
Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Japan
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CHIN Keigi
Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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TSUBATA Masahito
Department of Animal Science, Graduate School of Science and Technology, Kobe University
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WARITA Katsuhiko
Department of Bioresource and Agrobiosciences, Graduate School of Science and Technology, Kobe University
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